Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-05-06
1998-03-31
Degen, Nancy
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, 530350, A61K 3818, A61K 3817, C07K 1451
Patent
active
057338787
ABSTRACT:
Disclosed are methods and compositions for inducing periodontal tissue morphogenesis in a mammal which include a therapeutically effective concentration of a morphogen. The methods and compositions are useful for integrating an implanted tooth in a tooth socket and for inhibiting tissue loss associated with periodontal disease or injury.
REFERENCES:
patent: 4725234 (1988-02-01), Ethridge
patent: 4877864 (1989-10-01), Wang et al.
patent: 4919939 (1990-04-01), Baker
patent: 4968590 (1990-11-01), Kuberasampath et al.
patent: 4975526 (1990-12-01), Kuberasampath et al.
patent: 5011691 (1991-04-01), Oppermann et al.
patent: 5013649 (1991-05-01), Wang et al.
patent: 5106626 (1992-04-01), Parsons et al.
patent: 5108753 (1992-04-01), Kuberasampath et al.
patent: 5141905 (1992-08-01), Rosen et al.
patent: 5368859 (1994-11-01), Dunn et al.
patent: 5455041 (1995-10-01), Genco et al.
patent: 5459047 (1995-10-01), Wozney et al.
Sampath et al. (1983), "Homology of Bone-Inductive Proteins From Human, Monkey, Bovine, and Rat Extracellular Matrix," Proc. Natl. Acad. Sci. USA 80:6591-6595.
Mason (1985), "Complementary DNA Sequences of Ovarian Follicular Fluid Inhibin Show Precursor Structure and Homology with Transforming Growth Factor-.beta.," Nature 318:659-663.
Cate et al. (1986), "Isolation of the Bovine and Human Genes for Mullerian Inhibiting Substance and Expression of the Human Gene in Animal Cells," Cell 45:685-698.
Miller et al. (1987), "Phenotypic Modulation of the Swarm Rat Chondrosarcoma Induced by Morphogenetic Bone Matrix," Cancer Research 42:3589-3594.
Badgett et al. (1987), "A Transcript from a Drosophila Pattern Gene Predicts a Protein Homologous to the Transforming Growth Factor-.beta. Family," Nature 325:81-84.
Weeks et al. (1987), "A Maternal mRNA Localized to the Vegetal Hemisphere Xenopus Eggs Codes for a Growth Factor Related to TGF-.beta.," Cell 51:861-867.
Rosen et al.; Wozney et al.; Wang et al. (1988) Calcified Tissue International 42 (Suppl.): A35 (Abstr. No. 136); A37 (Abstr. No. 146 and 147).
Wang et al. (1988), "Purification and Characterization of Other Distinct Bone-Inducing Factors," Proc. Natl. Acad. Sci. USA 85:9484-9488.
Wozney et al. (1988), "Novel Regulators of Bone Formation: Molecular Clones and Activities," Science 242:1528-1533.
Dahlin et al. (1989), "Generation of New Bone Around Titanium Implants Using A Membrane Technique: An Experimental Study in Rabbits," 4 Int. J. Oral Maxillofac. Implants 19-25.
Lyons (1989), "VGR-1, A Mammalian Gene Related to Xenopus VG-1, is a member of the Transforming Growth Factor Beta Gene Superfamily", Proc. Nat. Acad. Sciences 86:4554-4558.
Lyons et al. (1989), "Patterns of Expression of Murine VGR-1 and BMP-2a RNA Suggest That Transforming Growth Factor-.beta.-Like Genes Coordinately Regulate Aspects of Embryonic Development," Genes & Development 3:1657-1668.
Mason et al. (1989), "Activin B: Precursor Sequences, Genomic Structure and in Vitro Activities," Molecular Endocrinology 3 (No. 9):1352-1358.
Rosen et al. (1989), "Purification and Molecular Cloning of a Novel Group of BMPs and Localization of BMP mRNA in Developing Bone," 20 Conn. Tissue Res. 313-319.
Behringer et al. (1990), "Abnormal Sexual Development in Transgenic Mice Chronically Expressing Mullerian Inhibiting Substance," Nature 345:167-170.
Celeste et al. (1990), "Identification of Transforming Growth Factor Beta Family Members Present in Bone-Inductive Protein Purified from Bovine Bone," Proc. Nat. Acad. Sciences 87:9843-9847.
Green et al. (1990), "Graded Changes in Dose of a Xenopus Activin A Homologue Elicit Stepwise Transitions in Embryonic Cell Fate," Nature 347:391-394.
Katagiri et al. (1990), "The Non-Osteogenic Mouse Pluripotent Cell Line, C3H10T1/2, Is Induced to Differentiate Into Osteoblastic Cells By Recombinant Human Bone Morphogenetic Protein-2," Biochem. Biophys. Res. Comm 172:1:295-299.
Lee (1990), "Identification of a Novel Member (GDF-1) of the Transforming Growth Factor-.beta. Superfamily," Molecular Endocrinology 4 (No. 7):1034-1040.
Nakashima (1990), "The Induction of Reparative Dentine In The Amputated Dental Pulp of the Dog By Bone Morphogenetic Protein," 35 Arch. Oral Biol. 7:493-497.
Ozkaynak et al. (1990), "OP-1 cDNA Encodes an Osteogenic Protein in the TGF-.beta. Family," EMBO J. 9 (No. 7):2085-2093.
Panaganiban et al. (1990), "Biochemical Characterization of the Drosophila dpp Protein, a Member of the Transforming Growth Factor .beta. Family of Growth Factors," Molecular and Cellular Biology 10, (No. 6) 2669-2677.
Rosen et al.; Celeste et al. (1990), J. Cell. Biochem.; Supplement 14E 33 (Abstr. No. 0-004); 54 (Abstr No. 0-105).
Sampath et al. (1990), "Bovine Osteogenic Protein Is Composed of Dimers of OP-1 and BMP-2A, Two Members of the Transforming Growth Factor-.beta. Superfamily," J. Biol. Chem. 265:13198-13205.
Schubert et al. (1990), "Activin is a Nerve Cell Survival Molecule," Nature 344:868-870.
Smith et al. (1990), "Identification of a Potent Xenopus Mesoderm Inducing Factor as a Homologue of Activin A," Nature 345:729-731.
Smith et al. (1990), "In vivo Morphogenetic Activity of Dentine Matrix Proteins," 18 J. Biol. Buccale:123-129.
Smith et al. (1990), "Preliminary Studies on the in vivo Morphogenetic Properties of Dentine Matrix Proteins," 11 Biomaterials.
Sokol et al. (1990), "A Mouse Macrophage Factor Induces Head Structures and Organizes a Body Axis in Xenopus," Science 249:561-563.
Wang et al. (1990), "Recombinant Human Bone Morphogenetic Protein Induces Bone Formation," Proc. Natl. Acad. Sci. USA 87:2220-2224.
Wozney et al. (1990), "Growth Factors Influencing Bone Development," J. Cell Sci. Suppl. 13:149-156.
Wozney (1990), "Bone Morphogenic Proteins," 1 Prog. In Growth Factor Res. 267-280.
Yannas (1990), "Biologically Active Analogues of the Extracellular Matrix: Artificial Skin and Nerves," Angew. Chem. Int. Ed. Engl. 29:20-35.
Caplan (1991), "Mesenchymal Stem Cells," J. Orthop. Res. 9:641-650.
Chen et al. (1991), "Bone Morphogenetic Protein-2b Stimulation of Growth and Osteogenic Phenotypes in Rat Osteoblast-like Cells: Comparison with TGF-.beta.," J. Bone Min. Res. 6:1387-1393.
D'Allessandro et al. (1991), J. Cell Biochem. Suppl. 15F (Abstr. No. 105).
Israel et al. (1991),Abstract Q-111 J. Cell Biochem. Suppl.
Lee (1991), "Expression of Growth/Differentiation Factor 1 in the Nervous System: Conservation of a Bicistronic Structure," Proc. Natl. Acad. Sci. USA 88:4250-4254.
Ozkaynak et al. (1991), "Murine Osteogenic Protein (OP-1): High Levels of mRNA in Kidney," Biochem. Biophys. Res. Comm. 179:116-123.
Takuwa et al. (1991), "Bone Morphogenetic Protein-2 Stimulates Alkaline Phosphatase Activity and Collagen Synthesis In Cultured Osteoblastic Cells, MC3T3-E1," Biochem. Biophys. Res. Comm. 174:1; 96-101.
Wharton et al. (1991), "Drosophilia 60A Gene, Another Transforming Growth Factor .beta. Family Member, is Closely Related to Human Bone Morphogenetic Proteins," Proc. Natl. Acad. Sci. USA 88:9214-9218.
Yamaguchi et al. (1991), "Recombinant Human Bone Morphogenetic Protein-2 Stimulates Osteoblastic Maturation and Inhibits Myogenic Differentiation In Vitro," J. Cell. Biol. 113:681-687.
Israel et al. (1992), "Expression and Characterization of Bone Morphogenetic Protein-2 in Chinese Hamster Ovary Cells," Growth Factors 7:139-150.
Rogers et al. (1992), "Bone Morphogenetic Proteins-2 and -4 are Involved in the Retinoic Acid-Induced Differentiation of Embryonal Carcinoma Cells," Mol. Biol. Cell 3:2; 189-196.
Thesleff (1995), "Homeobox Genes and Growth Factors In Regulation of Craniofacial and Tooth Morphogenesis," 53 Acta Odontol. Scand. 129-134.
Tureckova et al. (1995), "Comparison of Expression of the msx-1, msx-2, BMP-2 and BMP-4 Genes in the Mouse Upper Diastemal and Molar Tooth Primordia," 39 Int. J. Dev. Biol. 459-468.
Thesleff et al. 1995), "Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs," 39 Int. J. Dev. Biol. 35-50.
Vaahtokari et al. (1996), "The enamel knot as a signaling center in the developing mouse tooth," 54 Mechanisms of Development 39-43.
Cohen Charles M.
Kuberasampath Thangavel
Oppermann Hermann
Pang Roy H. L.
Rueger David C.
Creative BioMolecules, Inc.
Degen Nancy
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