Sustained release pharmaceutical composition

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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Details

424468, 424474, 424475, 424480, 424482, 424494, 424497, 427213, A61K 916, A61K 922, A61K 930, B05D 700

Patent

active

053307666

ABSTRACT:
The present invention relates to a pharmaceutical pellet composition having a core element including at least one highly soluble active ingredient and a core coating which is partially soluble at a highly acidic pH. The pharmaceutical composition provides a slow release of active ingredient at a highly acidic pH and provides a constant, relatively faster rate of release at a more alkaline pH such as that of the intestine. Oral administration of the pharmaceutical pellet composition of the present invention to a patient is effective to deliver to the blood levels of active ingredient within the therapeutic range and to maintain such levels over an extended period of time.

REFERENCES:
patent: 4806361 (1989-02-01), Harrison et al.
patent: 5068112 (1991-11-01), Samejima et al.

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