Method of producing cephem compounds

Details Method of producing cephem compounds Method of producing cephem compounds

1987-01-14

1990-03-13

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540222, 540228, C07D50104, A61K 31545

Patent

active

049084445

ABSTRACT:
A method of producing 3-alkanoyloxymethyl-3-cephem-4-carboxylic acids, which are useful as antibiotics or as intermediates in the synthesis of antibiotics, by reacting a 3-hydroxymethyl-3-cephem-4-carboxylic acid with a saturated fatty acid anhydride in an aqueous medium in the presence of an acid-acceptor base and a 4-(tertiary amino)pyridine.

REFERENCES:
patent: 3532694 (1970-10-01), Samefield et al.
patent: 3728342 (1973-04-01), Kukolja
Yamana et al, Jour. of Antibiotics vol. XXVII No. 12, p. 1000 (1974).
Heyningen, Jour. of Medicinal Chemistry vol. 10, pp. 22-25 (1965).
Van Heyningen, Journal of Medicinal Chemistry, vol. 8, pp. 22-25 (1965).

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