Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-04-16
1985-08-06
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514387, 546 15, 548309, A61K 3141, C07D47120, C07D48710
Patent
active
045336679
ABSTRACT:
A series of novel spiro-oxindole imidazolidinedione derivatives have been prepared, including their pharmaceutically acceptable salts. These compounds are useful in therapy as aldose reductose inhibitors for the control of certain chronic diabetic complications. Preferred compounds include 6'-amino-spiro-[imidazolidine-4,3'-indoline]-2,2',5-trione, 5'-chloro-7'-aminospiro-[imidazolidine-4,3'-indoline]-2,2',5-trione, 1'-(3-pyridylmethyl)-5'-fluoro-spiro-[imidazolidine-4,3'-indoline]-2,2',5- trione, 1'-(3-pyridylmethyl)-5',7'-dichloro-spiro-[imidazolidine-4,3'-indoline]-2, 2',5-trione and spiro-[imidazolidine-4,3'-(6-azaindoline)]-2,2',5-trione. Methods for preparing these compounds from known starting materials are provided.
REFERENCES:
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patent: 4443465 (1984-04-01), Brittain et al.
H. Otomasu et al., "Spiro Heterocyclic Compounds, I. Synthesis of Spiro-[imidazoline-4,3'-indoline]-2,2',5-triones", Chem. Pharm. Bull., (Tokyo), vol. 23, No. 7, p. 1431, (1975).
Bond Robert T.
Knuth Charles J.
Pfizer Inc.
Richardson Peter C.
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