Prolonged local anesthesia with colchicine

Details Prolonged local anesthesia with colchicine Prolonged local anesthesia with colchicine

1996-03-26

1998-05-05

Woodward, Michael P.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

4241951, 424489, 514818, 514825, 514951, 514963, A61K 914, A61K 952

Patent

active

057470600

ABSTRACT:
A formulation for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible nerve blockade when implanted or injected in a patient, and an amount of colchicine effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without colchicine.

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