System for automatic feedback-controlled administration of drugs

Details System for automatic feedback-controlled administration of drugs System for automatic feedback-controlled administration of drugs

1982-08-25

1985-08-06

Kamm, William E.

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

128731, A61M 500

Patent

active

045333467

ABSTRACT:
A system for automatic feedback controlled administration of drugs (SAFCAD) is disclosed for the control of administration of drugs responsive to real-time processed physiological or pharmacological signals. Control apparatus implemented by analog, digital, or optimal-adaptive digital means is described using various combinations of proportional, integral and derivative control loop processes. A preferred digital embodiment uses optimal-adaptive, proportional-integral control which includes on-line physiological system modeling and control loop parameter tuning for the administration of anesthetics such as thiopental.

REFERENCES:
patent: 2690178 (1954-09-01), Bickford
patent: 3837339 (1974-09-01), Aisenberg et al.
patent: 3882861 (1975-05-01), Kettering et al.
patent: 4055175 (1977-10-01), Clemens et al.
patent: 4151845 (1979-05-01), Clemens
Fukui et al., "Proceedings of the San Diego Biomedical Symposium", 1974, pp. 273-278.

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