Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1985-06-19
1990-03-13
Deck, Randall E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 32, 435 34, 435 39, C12Q 168, C12Q 118, C12Q 104, C12Q 106
Patent
active
049083082
ABSTRACT:
This invention concerns a method for identifying in vitro an animal-infective form of a parasitic protozoan which comprises recovering total mRNA from the protozoan and detecting in the mRNA so recovered the presence of a mRNA transcript encoding a heat shock protein associated with animal-infective parasitic protozoans, which transcript is present only in the animal-infective form of the protozoan, or quantitatively determining in the mRNA so recovered the number of a mRNA transcript encoding a heat shock protein associated with animal-infective parasitic protozoans, which transcript is present in increased number only in the animal-infective form of the parasitic protozoan.
This invention also concerns a method for identifying an agent capable of blocking the formation of the animal-infective form of a parasitic protozoan.
REFERENCES:
patent: 4556643 (1985-12-01), Paau et al.
Hunter et al., (1984), Biochemical and Biophysical Research Communications, vol. 125, No. 2, pp. 755-760.
Schlesinger et al., (1982), Heat Shock from Bacteria to //// Cold SPring Harber Laboratory, pp. 2-7, 419-422.
Zimmerman et al., (1983), Cell, vol. 32, pp. 1161-1170.
Fong et al., (1984), Proceedings of the National Academy of Science, U.S.A., vol. 81, pp. 5782-5786.
Schmur et al., (1983), Chemical Abstracts, vol. 99, No. 15, p. 370, Item No. 119186z.
Cantor Charles R.
Giannini Suzanne H.
Van der Ploeg Lex H. T.
Deck Randall E.
The Trustees of Columbia University in the City of New York
White John P.
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