Erythromycin D and esters thereof

Details Erythromycin D and esters thereof Erythromycin D and esters thereof

1982-04-12

1985-01-29

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 72, 435 76, 435253, A61K 3171, C07H 1708

Patent

active

044965460

ABSTRACT:
Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising erythromycin D, 3",4"-di-O-acetylerythromcyin D, 3"-O-acetyl-4"-O-propionylerythromycin D and 4"-O-acetylerythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D.

REFERENCES:
patent: 3884903 (1975-05-01), Jones et al.
patent: 4363803 (1982-12-01), Hauske
Majer et al., J. Am. Chem. Soc., 99, pp. 1620-1622, (1977).
Jones et al., J. Med. Chem., 15, pp. 631-634, (1972).
Martin et al., J. Med. Chem., 15, pp. 635-638, (1972).
Bartner et al., J. Chem. Soc., Perkin I, pp. 1600-1624, (1979).

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