Alkyloxyamino substituted fluorenones and their use as protein k

Details Alkyloxyamino substituted fluorenones and their use as protein k Alkyloxyamino substituted fluorenones and their use as protein k

1997-04-18

1999-12-21

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514651, 544155, 546204, 548528, 564322, 564352, A61K 3140, A61K 31535, C07D295116

Patent

active

060049596

ABSTRACT:
The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).

REFERENCES:
patent: 3592819 (1971-07-01), Fleming et al.
patent: 3671587 (1972-06-01), Trexler et al.
patent: 3814770 (1974-06-01), Andrews et al.
patent: 4064347 (1977-12-01), Fleming et al.
patent: 4816450 (1989-03-01), Bell et al.
patent: 5189046 (1993-02-01), Burch et al.
patent: 5340931 (1994-08-01), Yamada et al.
patent: 5459262 (1995-10-01), Schmitz
patent: 5514719 (1996-05-01), LaTorse et al.
Fu et al, J. Org. Chem., 56, pp. 1683-1685 (1991).
de Silva et al, Tetrahedron, vol. 48, No. 23, pp. 4863-4878 (1992).
Ladd, D., et al, J. Med. Chem. 29, pp. 1904-1912 (1986).
Sill, A., et al, J. Medicinal Chem., vol. 16, No. 3, pp. 240-245 (1973).
Miller, M., et al, J. Am. Chem. Soc., 102, pp. 7026-7032 (1980).
Bradshaw, D., et al, Agents Actions 38, pp. 135-147 (1993).
Davis, P., et al, FEBS Letters, vol. 259, No. 1, pp. 6-63 (1989).
Chemical Abstracts, vol. 62 (1965).
Chemical Abstracts, vol. 65 (1966).
Sala, T. et al, J. Chem. Soc. Perkin Trans. I, pp. 2593-2598 (1979).
Andrews, E.R., et al, J. Medicinal Chem. vol. 17, No. 8, pp. 882-886 (1974).
Sargent, M.V., J. Chem. Soc. Perkin Trans., 1, pp. 2553-2563 (1987).
Fu, J.-M., et al, Can. J. Chem., vol. 72, pp. 227-236 (1994).
Wang, W. et al, J. Org. Chem., 57, pp. 424-426 (1992).
Meyers, A., et al, J. Org. Chem., vol. 39, No. 18, pp. 2787-2793 (1974).
Meyers, A., et al, J. Am. Chem. Soc. Comm., 97:25, pp. 7383-7385 (1975).
Morgan, G., et al, J. Chem. Soc. Perkin Trans. I, pp. 2691-2696 (1926).
Mohindra, H., et al, Indian J. of Chem., vol. 26B, pp. 992-993, (Oct. 1987).
Gant, T., et al, Tetrahedron, vol. 30, No. 8, pp. 2297-2360 (1994).
Reuman, M., et al, Tetrahedron, vol. 40, No. 5, pp. 837-860 (1985).
Hannun, Y., et al, J. of Biological Chem., vol. 262, No. 28, pp. 13620-13626, (Oct. 5, 1987).
Wilson, E., et al, J. of Biological Chem., vol 261, No. 27, pp. 12616-12623 (Sep. 25, 1986).
Castagna, M., et al, J. of Biological Chem., vol. 262, No. 13, pp. 7847-7851, (Jul. 10, 1982).
Pittet, D. et al, J. Biological Chem.,vol. 262, pp. 10072-10076 (Jul. 25, 1987).
Fujita, I., et al, Biochemical Pharmacology, vol. 35, No. 24, pp. 4555-4562 (1886).
Gaudry, M., et al, Immunology, 63, pp. 715-719 (1988).
Yamada, K., et al, Biochemical Pharmacology, vol. 37, No. 6, pp. 1161-1166 (1988).
Berkow, R., et al, J. of Leukocyte Biology, 41, pp. 441-446 (1987).
Schachtele, C., et al, Biochemical and Biophysical Research Comm., vol. 151, No. 1, pp. 542-547 (Jan. 29, 1988).
Salzer, W., et al, Biochem. Biophys. Res. Comm., vol. 148, No. 2, pp. 747-754 (Oct. 29, 1987).
Dewald, B., et al, Biochem. J., 264, pp. 879-884 (1989).
Kramer, I., et al, J. Biological Chem., vol. 264, No. 8, pp. 3818-3822 (Mar. 15, 1988).
Lambeth, J., et al, J. of Biological Chem., vol. 263, No. 8, pp. 3818-3822 (Mar. 15, 1988).
McIntyre, T., et al, J. Biological Chem., vol. 262, No. 32, pp. 15370-15376 (Nov. 15, 1987).
Dodd, J., Synthetic Communications, 23(7), pp. 1003-1008 (1993).
Barker, A., et al, J. Chem. Soc. 870 (1954).
Colste, J. et al, Tetrahedron Letters, vol. 31, No. 2, pp. 205-208 (1990).
Martinez, J. et al, J. Med. Chem., 28, pp. 1874-1879 (1985).
Frerot E., et al, Tetrahedron Letters, vol. 47, No. 2, pp. 259-270 (1991).
Hoeg-Jensen, T. et al, Tetrahedron Letters, vol. 32, No. 51, pp. 7617-7620 (1991).
Calbiochem-Novabiochem. Corp. Catalog pp. 162-165.
Jones, Winton et al, J. Org. Chem., vol. 61, No. 11, pp. 3920-3922.

Affiliated with

Also associated with

Rating

Alkyloxyamino substituted fluorenones and their use as protein k does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alkyloxyamino substituted fluorenones and their use as protein k, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alkyloxyamino substituted fluorenones and their use as protein k will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-505374