Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-de

Details Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-de Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-de

1992-10-14

1995-07-11

Chereskin, Che S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2714, 536 282, C07H 1906

Patent

active

054322731

ABSTRACT:
A process for the preparation of 3'-substituted-2',3'-dideoxynucleosides is provided that utilizes inexpensive, non-carbohydrate, acyclic, achiral starting materials and that proceeds with high enantiomeric and stereochemical control. The method can be used to prepare the pharmaceutically important compounds 3'-azido-3'-deoxythymidine, 3'-azido-2',3'-dideoxyuridine, 3'-fluoro-3'-deoxythymidine, and 3'-fluoro-3'-deoxyuridine.

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