Human lysophospholipase

Details Human lysophospholipase Human lysophospholipase

1998-12-17

1999-12-21

Achutamurthy, Ponnathapu

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435197, C12N 920

Patent

active

060047925

ABSTRACT:
The invention provides a new human lysophospholipase (IHLP) and polynucleotides which identify and encode IHLP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating inflammation and disorders associated with expression of IHLP.

REFERENCES:
patent: 5858756 (1999-01-01), Hillman et al.
Sugimoto, H., et al., "Purification, cDNA Cloning, and Regulation of Lysophospholipase from Rat Liver," The Journal of Biological Chemistry, 271(13):7705-7711 (1996) (GI 1552244).
Selle, H., et al., "Glycerophosphocholine release in human erythrocytes," Eur. J. Biochem, 212:411-416 (1993).
Endresen, M., et al., "Increased lipolytic activity of sera from preeclamptic women due to the presence of a lysophospholipase," Scand. J. Clin Lab Invest, 53:733-739 (1993).
Anderson, R., et al., ".alpha.-Tocopherol Prevents Cyclosporin A-Mediated Activation of Phospholipase A.sub.2 and Inhibition of Na+, K.sup.+ -;Adenosine Triphosphatase Activity in Cultured Hamster Renal Tubular Cells," Toxicology and Applied Pharmacology, 125:176-183 (1994).
Hong, K., et al. (GI 244500 and GI 244501) GenBank Sequence Database (Accession S79600), National Center for Biotechnology Information National Library of Medicine, Bethesda, Maryland 20894, No date provided.
Sugimoto, H., et al., "Purification, Characterization, and Inhibition by Phosphatidic Acid of Lysophospholipase Transacylase from Rat Liver," The Journal of Biological Chemistry, 269(8):6252-6258 (1994).
Database EMST 8, E.M.B.L. Databases, Accession Number: AA417842, May 14, 1997, National Cancer Institute: "Homo sapiens cDNA clone Image: 746208 5' similar to WP: K04G2.5 CE06099 Esterase".
Wang, A. et al., "Cloning, Expression, and Catalytic Mechanism of Murine Lysophospholipase I", J. Biol. Chem., 272(19): 12723-12729 (1997).
Garsetti, D. et al., "Butyric acid-induced differentiation of HL-60 cells increases the expression of a single lysophospholipase", Biochem. J., 288: 831-837 (1992).
Sugimoto, H., et al. (GI 1552243 and GI 1552244) GenBank Sequence Database (Accession D63885), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894, Sep. 19, 1996.
Hillier, L. et al. (GI 1423869) GenBank Sequence Database (Accession W94749), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894, Nov. 29, 1996.
Wells, J.A. et al., "Additivity of Mutational Effects in Proteins", Biochemistry, 29(37): 8509-8517 (1990).

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