Trifunctional conjugates

Details Trifunctional conjugates Trifunctional conjugates

1991-09-30

1992-12-01

Naff, David M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

435 79, 435 792, 435 793, 435177, 435181, 435964, 436518, 436528, 436532, 436537, 436544, 436545, 436819, 530810, 530812, 530816, C12N 1100, C12N 1106, G01N 33547, G01N 33532

Patent

active

051680572

ABSTRACT:
A trifunctional conjugate is provided having three chemical moieties, attached through a spacer moiety. At least two of the chemical moieties are relatively small molecules, usually less than about 7,000 Daltons in size. The spacer moiety is selected to impart certain steric properties to the conjugate. In one embodiment, the binding of a macromolecular specific binding partner to one of the chemical mouths sterically inhibits the binding of a different macromolecule to another chemical moiety. In another embodiment, the binding of a first chemical moiety to a macromolecule restricts the subsequent binding of a second chemical moiety to a proximate location on the same macromolecule.

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