Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-06-14
1994-08-23
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514256, 514357, 514617, 514618, 514619, 544326, 544327, 546309, 546336, 564161, 564162, 564163, 564165, 564170, 564171, 564172, 564180, A61K 3144, C07D21375
Patent
active
053408276
ABSTRACT:
##STR1## Compounds of formula (1) are described wherein Y represents a halogen atom or a group --OR.sup.1 where R.sup.1 represents an optionally substituted alkyl group; R.sup.2 represents an optionally substituted cycloalkylcycloalkenyl or polycycloalkyl group; R.sup.3 represents a hydrogen atom or an alkyl, aryl or aralkyl group; R.sup.4 represents an aryl or heteroaryl group; X represents --O--, --S--, --CH.sub.2 -- or --N(R.sup.5)--, where R.sup.5 is a hydrogen atom or an alkyl group; n is zero or an integer or value 1, 2 or 3; and the salts, solvates and hydrates thereof. The compounds are selective phosphodiesterase IV inhibitors and are useful for the prophylaxis or treatment of inflammatory diseases.
Beeley Nigel R. A.
Millican Thomas A.
Celltech Limited
Davis Zinna N.
Ivy C. Warren
LandOfFree
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