Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-11-09
1994-08-23
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544272, C07D47304, A61K 3152
Patent
active
053408136
ABSTRACT:
Compounds of the formula ##STR1## wherein each of one or two R is independently ##STR2## wherein n is an integer from 4 to 18, each R.sub.1 ' and R.sub.2 ' is independently H, alkyl (1-4C) or alkenyl (1-4C); and R.sub.3 ' and R.sub.4 ' are independently H or CH.sub.3 ; and wherein the alkyl or alkenyl may be substituted by a hydroxyl, halo or dimethylamino group and/or interrupted by an oxygen atom, H or alkyl (1-4C), including resolved enantiomers and/or diastereomers and mixtures thereof. Preferably, n is from 6 to 10, R.sub.1 ' and R.sub.2 ' are independently H or methyl and R.sub.3 ' and R.sub.4 ' are H. In particular, the compounds lower elevated levels of unsaturated, non-arachidonate phosphatidic acid (PA) and diacylglycerol (DAG) derived from said PA within seconds of the primary stimulus and their contact with said cells. The modulatory effect depends on the nature of the target cell and the stimulus applied.
REFERENCES:
patent: 4061753 (1977-12-01), Godor et al.
patent: 4275064 (1981-06-01), Bodor et al.
patent: 4565817 (1986-01-01), Korbonits et al.
patent: 4618612 (1986-10-01), Baglioni et al.
patent: 5039666 (1991-08-01), Novick, Jr.
Klein J. Peter
Leigh Alistair
Underiner Gail
Cell Therapeutics Inc.
Oster Jeffrey B.
Shah Mukund J.
Sripada P. K.
LandOfFree
Substituted aminoalkyl xanthine compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted aminoalkyl xanthine compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted aminoalkyl xanthine compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-503224