Method and compositions for treating tumors having high tyrosina

Details Method and compositions for treating tumors having high tyrosina Method and compositions for treating tumors having high tyrosina

1993-05-05

1994-08-23

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 41, 536 179, 536 53, A01N 4304, A61K 3170, C07G 300, C07H 1500

Patent

active

053408039

ABSTRACT:
Tumor cells which have .beta.-glucuronidase and tyrosinase activity are selectively treated by administration of a conjugate of a cytotoxic compound which is a substrate for tyrosinase and glucuronic acid or a pharmaceutically acceptable salt or ester thereof particularly the methyl-triacetylated form of glucuronic acid. Among the cytotoxic phenolic compounds which are substrates for tyrosinase which can be used are 4-hydroxyanisole, butylated hydroxyanisole, L-3,4-dihydroxy-phenylalanine, dopamine (3,4-dihydroxyphenethylamine), terbutylcatechol, hydroquinone, resorcinol, 6-hydroxydopa (3,4,6-trihydeoxyphenylalanine) and methyl gallate.
The efficacy of the treatment is enhanced by also administering a compound that inhibits the action of glutathione reductase.

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