Simultaneous calibration heterogeneous immunoassay

Details Simultaneous calibration heterogeneous immunoassay Simultaneous calibration heterogeneous immunoassay

1992-08-28

1995-07-11

Bidwell, Carol E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 792, 435805, 435810, 435967, 435970, 435975, 422 56, 422 57, 422 61, 422 66, G01N 33543

Patent

active

054320577

ABSTRACT:
An assay method and compositions are provided for determining the presence of an analyte in a sample. The analyte is a member of an immunological pair (mip) comprising ligand and receptor. By providing a first measurement surface capable of specifically binding a labelled reagent in an amount depending upon the presence of analyte in the sample and a second calibration surface capable of binding a second labeled reagent in a manner unaffected by the presence of analyte in the sample, calibration of individual tests can be accomplished simultaneously with the performance of the test itself. A signal producing system includes an enzyme, a catalyst usually bonded to a mip which defines the first labeled reagent for binding to the measurement surface and the same catalyst conjugated to a ligand capable of binding to the calibration surface. Preferably, both labeled reagents have the same composition and the calibration surface includes anti-(first catalyst).

REFERENCES:
patent: 4059407 (1977-11-01), Hochstrasser
patent: 4157895 (1979-06-01), Finlay et al.
patent: 4294817 (1981-10-01), Burgett et al.
patent: 4366241 (1982-12-01), Tom et al.
patent: 4849338 (1989-07-01), Litman et al.
patent: 5342759 (1994-08-01), Litman et al.

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