Aspiration screening process for assessing post surgery patient'

Surgery – Diagnostic testing

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600529, 128898, A61B 500

Patent

active

060042680

ABSTRACT:
Whether a post surgery intubated patient is at risk for aspiration-based pneumonia is determined by requiring the patient to inhale an aerosol of tartaric acid that will stimulate a sensory innervation of the patient's larynx, if functionally recovered, thereby causing the patient to cough. The resulting cough or lack of cough is graded to determine whether the patient is at risk for pneumonia caused by the aspiration of matter present in the patient's mouth. In a further embodiment, the inability or difficulty of a patient to voluntarily expel potentially threatening fluid and matter from the patient's airway can be remedied by repeated applications of the aerosol chemostimulant spray.

REFERENCES:
Florida Hospital Association 1996--"Cost of Dysphagia Testing and treatment of Aspirating Pneumonia." (single sheet) dated Sep. 24, 1997.
Merck Index. 12th ed. 1996 "Tartaric Acid", p. 1552.
United States Department of Labor, Occupational Safety and Health Administration. material Safety Data Sheet (MSDS) on Tartaric Acid (2 sheets).
Addendum to MSDS on Tartaric Acid. "Regulatory Status" (6 sheets).
Partial Listing of OTC Inhalers with Bitartrate. (Single Sheet).
Patty's Industrial Hygiene and Toxicology Vol. 2C 1982 "Tartaric Acid" pp. 4937,4743-5, 4981-2.
Chasseaud LF, Down WH, Kirkpatrick D. 1977 Absorption and Biotransformation of L(+)-Tartaric Acid in Rats. Experientia 33:998-1003.
Fassett DW. Organic Acids, Anhydrides, Lactones, Acid Halides and Amides, Thioacids in Industrial Hygiene and Toxicology 2nd ed. vol. II. DW Fassett and DD Irish, eds., Wiley-Interscience, New York. 1963. pp. 1771-7, 1811, 1814.
Fithugh OG, Nelson AA. 1947 The Comparative Chronic Toxicities of Fumaric, Tartaric, Oxalic and Maleic Acids. J AM Pharm Assocs 36:217-9.
Horn HJ, Holland EG, Hazleton LW. 1957 Safety of Adipic Acid as Compared with Citric and Tartaric Acid. J Agric Food Chem 5:759-61.
Lewis JD. 1977 Comparison of the Distribution of L(+) and DL-Forms of Tartaric Acid in the Rat. Acta Pharmacol Toxicol 41:144-5.
Locke A, Locke RB, Schlesinger H, Carr H. 1942 The Comparative Toxicity and Cathartic Efficiency of Disodium Tartrate and Fumarate, and Magnesium Fumarate for the Mouse and Rabbit, J AM Pharm Assoc 31;12-14.
Smyth Jr. HF, Carpenter CO, Weill CS, Pozzani UC, Striegel JA. 1962 Range-Finding Toxiicity Data: List VI. Am Ind. Hyg. ASsoc J23:95-107.
Sourkes TL, Koppanyi T. Correlation Between the Acute Toxicity and the Rate of Elimination of Tartaric Acid and Certain of its Esters 1950. J AM Pharm Assoc. 39:275-6.
Underhill FP, Leonard CS, Gross EG, Jaleski, TC. 1931. Studies on the Metabolism of Tartrates: II The Behavior of Tartrate in the Organism of the Rabbit, Dog, Rat and Guinea Pig. J Pharmacol 43:359-80.
Weiss JM, Downs CR, Corson HP. 1923 Inactive Malic Acid as a Food Acidulent. Ind Eng Chem 15:628-30. Also cited by Registry of Toxic Effects of Chemical Substances, NIOSH ed., 1978.
Who Food Additives Series, No. 5, "Toxicological Evaluation of Some Food Additives Including Anticaking Agents, Antimocrobials, Antioxidants, Emulsifiers and Thickening Agents." [17th Report of the Joint FAO/Who Expert Committee on Food Additives, SHO Technical Report Series, 1974, No. 539; FAO Nutrition Meetings Report Series, 1974, No. 53] Geneva. pp. 14, 222-4, 236-7, 512-4.
Addington WR, Stephens RE, Ockey RR, Kann D, Rodriguez M. A New Aspiration Screening Test to Assess the Need for Modified Barium Swallow Study. Archives of Physical Medicine and Rehabilitation Nov. 1995:76(11):1040.
Addington WR, Stephens RE, Gilliland K, Miller SP. The Laryngeal Evoked Potential (LEP) and Laryngeal Cough Reflex, Muscle and Nerve, Aug. 1997; 20(3); 1071-1072.447.
Alberts MJ, Horner J, Gray L. Brazer SR. Aspiration After Stroke: Lesion analysis by Brain MRI. Dysphagia. 7(3):170-3, 1992.
Alessi DM, Berci G. Aspiration and Nasogastric Intubation. Otolaryngology--Head and Neck Surgery. 94(4):486-9, Apr. 1986.
Aubert M, Guilhen C. Topographie des Projections de la Sensibilite Viscerale Sur L'ecorce Cerebrale du Chat. 3. Etude des Projections Corticales du Nerf Larynge Superieur. Archives Italiennes de Biologie Nov. 1971:109(3):236-52.
Bandler R, Tork I. Midbrain Periaqueductal Grey Region in the Cat has Afferent and Efferrent Connections with Solitary Tract Neuclei. Neuroscience Letters Feb. 10, 1987; 74(1):106.
Barillot JC, Mei N. Modification, Au Niveau du Noyau du Faisceau Solitaire, de l'Excitabilite des Terminaisons de Fibres Vagales ou Laryngees d'origine connue. 1964 Etude Unitaire, pp. 395-396.
Berger A.J. Dorsal Respiratory Group Neurons in the Medulla of Cat: Spinal Projections, Responses to Lung Inflation and Superior Laryngeal Nerve Stimulation. Brain Research Oct. 28, 1977; 35(2):231-54.
Berkley KJ, Schofield SL. Relays from the Spinal Cord and Soitary Nucleus Through the Parabrachial Nucleus to the Forebrain in the Cat. Brain Research Oct. 8, 1990; 529 (1-2):333-8.
Boushey HA, Richardson PS, Widdicombe JG. Reflex Effects of Laryngeal Irritation on the Pattern of Breathing and Total Lung Resistance. Journal of Physiology Jul. 1972;224(2);501-13.
Boushey HA, Richardson PS, Widdicombe JF, Wise JC. The Response of Laryngeal Afferent Fibers to Mechanical and Chemical Stiimuli. Journal of Physiology Jul. 1974;240(1):153-75.
Callanan D, Dixon M, Widdicombe JG, Wise JC. Responses of Geese to Inhalation of Irritant Gases and Injections of Phenyl Diguanide, Respiration Physiology (1974) pp. 157-166.
Car A, Jean A, Roman C. A Pontine Primary Relay for Ascending Projections of the Superior Laryngeal Nerve. Exp. Brain Res. 1975; 22:197-210.
Choudry NB, Fuller RW. Sensitivity of the Cough Reflex in Pateints with Chronic Cough. European Respiratory Journal 5(3):296-300, Mar. 1992.
Chung, K, Ambrogio F, Sant Ambrogio G. The Fiber composition of the Superior Laryngeal Nerve. FASEB Journal 1993; 7:A402.
Daniels SK, Brailey K, Priestly DH, Herrington LR, Weisberg LA, Foundas AL. Aspiration in Patients with Acute Stroke. Arch Phys Med Rehabil vol. 79, Jan. 1998, pp. 14-19.
Das RM, Jeffery PK, Widdicombe JG. The Structure and Function of Intra-Epithelial Nerve Fibers of the REspiratory Tract in the Cat [Proceedings]. Journal of Physiology Aug. 1977;270(1):39P-40P.
Buchholz, DW. Dysphagia Associated with Neurological Disorders [Review] Acta Oto-Rhino-Laryngologica Belgica. 48(2):143-55,1994.
DePippo KL, Holas MA, Reding MJ. Validation of the 3-oz. Water Swallow Test for Aspiration Following Stroke. Arch. Neurol. Feb. 1994, vol. 5, pp. 119-120.
Dyachenko YE, Preobrazhensky NN. Funktsional'naia Differentsiatsiia Afferentov Verkhnegortannogo Nerve Koshki. [Russian: Functional Differentiation of Afferents of Superior Laryngeal Nerve in the Cat]. Neirofiziologiia 1984;16(6):777-83.
Droulias C, Tzinas S, Harlaftis N, Akin JT, Jr. Gray, SW, Skandalakis, JE. The Superior Laryngeal Nerve. American Surgeon Sep. 1976;42(( ):635-8.
Fujimura M, Sakamoto S, Kamio Y, Matsuda T. Cough Receptor Sensitivity and Bronchial Responsiveness in Normal and Asthmatic Subjects. European Respiratory Journal Mar. 1992;5(3):291-5.
Fujimura M, Sakamoto S, Kamio Y, Matsuda T. Effects of Methacholine Induced Bronchoconstriction and Procateral Induced Bronchodilation on Cough Receptor Sensitivity to Inhaled Capsaicin and Tartaric Acid. Thorax Jun. 1992;47(6);441-5.
Fujimura M, Sakamoto S, Kamio Y, Matsuda T. Sex Difference in the Inhaled Tartaric Acid Cough Treshold in Non-Atopic Healthy Subjects. Thorax Aug. 1990;45(8):633-4.
Fukuyama T, Umezaki T, Shin T. Detection of Laryngeal Sensory-Evoked Potentials (LSEPs) in the Cat. Oct. 1993 Amer. Academy of Otolaryngology., pp. 748-752.
Fuller R, Hansson L., Karlsson JA. Neurophysiology of the Cough Reflex [Letter]. European Respiratory Journal. 9(3):622-4, Mar. 1996.
Gerhardt T, Bancalari E. Maturational Changes of Reflex Influencing In Newborns. Amer. Physiological Society 1981. pp. 1282-1285.
Glogowska M., Stransky A., Widdicombe JF. Reflex Control of Discharge in Motor Fibers to the Larynx. Journal of Physiology. 239(2):368-79, Jun. 1974.
Guyton AC. Testbook of Medical Physiology (1991, 8th ed.) pp. 402-413.
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