Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1987-07-31
1991-03-05
Weimar, Elizabeth C.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
800DIG1, 800 2, 4353171, 935 32, C12N 1500
Patent
active
049977636
ABSTRACT:
A stable, substantially nononcogenic vector having a cloning site for the convenient insertion of a gene of interest has been constructed by recombinant technology from an avian retrovirus. The construct is derived from Rous sarcoma virus and the cloning site is a replacement for the csr oncogene. This vector is useful for ferrying selected, expressible genes into avian germ cells for incorporation into the germ line. The vector is also useful for inserting and expressing foreign genes in somatic avian cells both in vivo and in vitro.
REFERENCES:
H. L. Robinson et al., "Sequences Outside of the Long Terminal Repeat Determine the Lymphomogenic Potential of Rous-Associated Virus Type 1," J. Virol. 55(3): 752-759, (Sep. 1985).
Harriet L. Robinson et al., "At Least Two Regions of the Viral Genome Determine the Oncogenic Potential of Avian Leukosis Viruses," Proc. Natl. Acad. Sci. U.S.A. 79: 1225-1229, (Feb. 1982).
S. H. Hughes et al., "Genes for the Major Structural Proteins: Organization and Control of Expression," In Cold Spring Harbor annual report, pp. 81-86, (1981).
S. H. Hughes, "Sequence of the Long Terminal Repeat and Adjacent Segments of the Endogenous Avian Virus Rous-Associated Virus O," J. Virol. 43(1): 191-200, (Jul. 1982).
S. H. Hughes et al., "Genes for the Major Structural Proteins: Organization and Control of Expression," In Cold Spring Harbor annual report, pp. 85-92, (1982).
S. Hughes et al., "Retroviral Vectors," In Cold Spring Harbor annual report, pp. 66-68, (1983).
S. H. Hughes et al., "Gene Expression in Eucaryotes," In Litton Bionetics, Inc. Basic Research Program annual report, pp. VI-73 to VI-81, (1984).
S. Hughes et al., "Mutagenesis of the Region between env and src of the SR-A Strain of Rous Sarcoma Virus for the Purpose of Constructing Helper-Independent Vectors," Virology 136: 89-99, (1984).
S. H. Hughes et al., "Gene Expression in Eukaryotes Section," In Litton Bionetics, Inc. Basic Research Program annual report, pp. 138-147, (1985).
L. B. Crittenden et al., "Gene Insertion: Current Progress and Long-Term Goals," Avian Dis. 30(1): 43-46, (Jul. 23, 1985).
L. B. Crittenden et al., "Genetic Engineering to Improve Resistance to Viral Diseases of Poultry: A Model for Application to Livestock Improvement," Can. J. Anim. Sci. 65: 553-562, (Sep. 1985).
R. M. Shuman et al., "Gene Transfer by Avian Retroviruses," Poul. Sci. 65: 1437-1444, (Aug. 1986).
D. W. Salter et al., "Retroviruses as Vectors for Germ Line Insertion in the Chicken," Proc. Symp. on Molecular Approaches to Poultry Breeding and Disease Resistance, Third World Congress on Genetics Applied to Livestock Production, (in print Jul. 1986).
S. H. Hughes et al., "Design of Retroviral Vectors for the Insertion of Foreign Deoxyribonucleic Acid Sequences into the Avian Germ Line," Poul. Sci. 65: 1459-1467, (Aug. 1986).
D. W. Salter et al., "Gene Insertion into the Chicken Germ Line by Retroviruses," Poul. Sci. 65: 1445-1458, (Aug. 1986).
Crittenden Lyman B.
Hughes Stephen H.
Salter Donald W.
Chambers Jasemine C.
Fado John D.
Ribando Curtis P.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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