Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-07-14
1990-06-05
Springer, David B.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546167, 546144, 546268, 548159, 548217, 548336, 548454, 548455, C07D47102
Patent
active
049315668
ABSTRACT:
Process for the preparation of 1,4-diketopyrrolo[3,4-c]pyrroles of the formula I ##STR1## in which R.sub.1 and R.sub.2 independently of one another are phenyl, biphenyl or naphthyl radicals or aromatic O-heterocyclic, S-heterocyclic or N-heterocyclic radicals, by reacting 1 mole of a dicyclohexyl succinate, dialkyl succinate, monoalkylmonophenyl or diphenyl succinate, alkyl in the succinic acid ester radical being C.sub.1 -C.sub.18 alkyl and phenyl being phenyl which is unsubstituted or substituted by one or two halogen atoms or one or two C.sub.1 -C.sub.6 alkyl or C.sub.1 -C.sub.6 alkoxy groups, with 2 moles of a nitrile of the formula II or III or with 1 mole of a nitrile of the formula II and 1 mole of a nitrile of the formula III ##STR2## in which R.sub.1 and R.sub.2 are as defined above, in an inert organic solvent, in the presence of an alkali metal or an alkali metal alcoholate, as a strong base, and at an elevated temperature to give an alkali metal salt of the formula IV ##STR3## in which M is an alkali metal, and subsequently liberating a compound of the formula I by protolysis of a compound of the above formula IV, which comprises treating, in stages, a compound of the above formula IV in at least two portions, as a protolysing agent, with water, with an inorganic and/or organic acid, with a mixture of water and an organic solvent, or with a mixture of an inorganic or organic acid and water and/or at least one organic solvent, and reacting the mixture at a temperature from 20.degree. to 150.degree. C. after the addition of each of the portions.
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Iqbal Abul
Stern Christian
Surber Werner
Ciba-Geigy Corporation
O'Brien Stephen V.
Springer David B.
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