Method of reducing pre- and post-ischemic myocardial arrhythmias

Details Method of reducing pre- and post-ischemic myocardial arrhythmias Method of reducing pre- and post-ischemic myocardial arrhythmias

1989-02-15

1990-06-05

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3140

Patent

active

049314645

ABSTRACT:
Zofenopril, fosinopril, (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-oxohexyl]-L-proli ne or a pharmaceutically acceptable salt thereof alone or in combination with a thrombolytic, antiarrhythmic, or antifibrillatory agent is employed to reduce pre- and post- ischemic myocardial arrhythmias and fibrillations as well as reducing arrhythmias associated with congestive heart failure.

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Van Gilst et al., "Captopril reduces Purine Loss And Reperfusion Arrhythmias In The Rat Heart After Coronary Artery Occlusion," European Jour. of Pharmacology, vol. 100, pp. 113-117 (1984).
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