Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1987-07-06
1990-06-05
Moskowitz, Margaret
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4351722, 435 7021, 530387, 530809, 935104, 935108, 935110, C12N 500, C07K 1500, C07K 1504
Patent
active
049313959
ABSTRACT:
A hybrid cell line capable of producing monoclonal antibodies uniquely specific to human neutrophils. The monoclonal antibody has no reactivity with other human peripheral blood cells and virtually no reactivity with granulocyte precursors or other cells in bone marrow. Further, there is no reactivity with human acute leukemia cells. One of the partners in the hybridoma fusion of a mouse spleen cell developed from using highly purified human granulocytes as the immunization agent. The monoclonal antibody further is characterized by its capability of being used to enumerate and isolate neutrophils in normal peripheral blood and patients with acute leukemia.
REFERENCES:
P.A.T. Tetteroo et al., Neutrophil Activation Detected by Monoclonal Antibodies, J. Immuno. 136(9):3427-3432 (May, 1986).
Laskin, D. L. et al, "Stimulation of Human Neutrophilic Granulocyte Chemotaxis by Monoclonal Antibodies", J. Immunol. 134(2):1146-1152, Feb. 1985.
Melnick, D. A. et al., "Activation of Human Neutrophils by Monoclonal Antibody PMN7C3: Cell Movement and Adhesion Can Be Triggered Independently from the Respiratory Burst", Blood 67(5):1388-1394, May 1986.
Cass Myron C.
Cheney Kay E.
Dana-Farber Cancer Institute
Moskowitz Margaret
LandOfFree
Monoclonal antibody specific to neutrophils does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibody specific to neutrophils, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody specific to neutrophils will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-491406