Certain pyrroloquinolinones: a new class of GABA brain receptor

Details Certain pyrroloquinolinones: a new class of GABA brain receptor Certain pyrroloquinolinones: a new class of GABA brain receptor

1992-01-22

1993-09-07

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D47104, A61K 31475

Patent

active

052430499

ABSTRACT:
This invention encompasses compounds of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein X and Y are the same or different and represent oxygen or H.sub.2 with the proviso that not both X and Y are H.sub.2 ; W represents phenyl, thienyl, or pyridyl, each of which may be unsubstituted or momo or disubstituted with organic or inorganic substituents; and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are variables representing organic and inorganic substituents.
These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.

REFERENCES:
R. B. Roy et al., J. Chem. Soc. C., (14), 1886-1891 (1969).

Affiliated with

Also associated with

Rating

Certain pyrroloquinolinones: a new class of GABA brain receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Certain pyrroloquinolinones: a new class of GABA brain receptor , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Certain pyrroloquinolinones: a new class of GABA brain receptor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-488841