Process for preparing hypotensive 2-(4-aroylpiperazin-1-yl)-amin

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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C07D23995

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040628442

ABSTRACT:
Certain 2-(4-aroylpiperazin-1-yl)-4-amino-6,7-dimethoxyquinazolines are prepared by a novel process wherein certain 2-(4-substituted-piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline intermediates wherein said substituent is cyano, certain carbon-oxygen double bond containing groups or certain carbon-nitrogen double bond containing groups, are reacted with certain metalloaryl compounds followed by hydrolysis. The products are known hypotensive agents. Certain of the process intermediates are novel compounds.

REFERENCES:
patent: 3511836 (1970-05-01), Hess

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