Intermediates for polycyclic quinoid antibiotics

Details Intermediates for polycyclic quinoid antibiotics Intermediates for polycyclic quinoid antibiotics

1975-11-18

1978-01-24

Shaver, Paul F.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260396R, 424331, 424340, C07C 8710

Patent

active

040703827

ABSTRACT:
There is provided a novel method of synthesizing certain tetracyclic quinones. In particular, there is provided a novel route to the synthesis of (.+-.)-7-deoxydaunomycinone and analogs thereof, which includes the provision of novel tri- and tetracyclic quinone intermediates. The -7-deoxydaunomycinone derived from naturally occurring daunomycin is a known compound, which is itself an intermediate in the preparation of the clinically accepted anti-tumor antibiotics daunomycine and its derivative adriamycin.

REFERENCES:
patent: 3201424 (1965-08-01), McCormick
patent: 3665018 (1972-05-01), Jolles
patent: 3686163 (1972-08-01), Arcamone et al.
patent: 3803124 (1974-04-01), Arcamone et al.
patent: 3963760 (1976-06-01), Bernardi et al.
patent: 3976667 (1976-08-01), Kelly

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