Preparation of piperidinyl-alkyl-benzamides

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260295AM, 424267, C07D21136

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active

040353737

ABSTRACT:
New piperidinyl-alkyl-benzamides and salts thereof are disclosed, together with a method for the production of the benzamides and salts. The benzamides, which have beta-adrenergic agonist effects, have the general formula ##STR1## The hydrochlorides which exemplify the salts, have the general formula ##STR2## In the foregoing formulas R is hydrogen, an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, halo, amino, hydroxy or trifluoromethyl, n is 1, 2 or 3 when R is methoxy but is otherwise 1, and x is 1, 2 or 3. The hydrochloride salts of the benzamides according to the invention can be produced by the reactions illustrated below: ##STR3## Wherein R, n and x have the meanings set forth above and Y can be --Cl, --F, or --OCH.sub.3.

REFERENCES:
patent: 3342826 (1967-09-01), Miller et al.
patent: 3532704 (1970-10-01), Suter et al.
patent: 3862139 (1975-01-01), Podesva et al.
patent: 3891671 (1975-06-01), Thominet

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