Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-02-23
1977-07-12
Milestone, Norma S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260295AM, 424267, C07D21136
Patent
active
040353737
ABSTRACT:
New piperidinyl-alkyl-benzamides and salts thereof are disclosed, together with a method for the production of the benzamides and salts. The benzamides, which have beta-adrenergic agonist effects, have the general formula ##STR1## The hydrochlorides which exemplify the salts, have the general formula ##STR2## In the foregoing formulas R is hydrogen, an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, halo, amino, hydroxy or trifluoromethyl, n is 1, 2 or 3 when R is methoxy but is otherwise 1, and x is 1, 2 or 3. The hydrochloride salts of the benzamides according to the invention can be produced by the reactions illustrated below: ##STR3## Wherein R, n and x have the meanings set forth above and Y can be --Cl, --F, or --OCH.sub.3.
REFERENCES:
patent: 3342826 (1967-09-01), Miller et al.
patent: 3532704 (1970-10-01), Suter et al.
patent: 3862139 (1975-01-01), Podesva et al.
patent: 3891671 (1975-06-01), Thominet
Milestone Norma S.
Purdue John C.
The University of Toledo
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