Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1989-11-29
1993-09-07
Lacey, David L.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
5303888, 5303913, 5303871, C12N 512, C07K 1528
Patent
active
052428249
ABSTRACT:
The present invention relates to a novel monoclonal antibody reactive with human carcinoma cells. More particularly, the antibody of the invention is a monoclonal antibody reactive with a glycolipid cell membrane antigen on the surface of human carcinomas. The antibody displays a high degree of selectivity for carcinoma cells, showing a low degree of reactivity with certain normal human cells and no detectable reactivity with other types of tumors such as lymphomas, sarcomas or melanomas. In addition, the antibody of the invention is capable of internalizing within the carcinoma cells to which it binds and is therefore particularly useful for therapeutic applications, for example, as the antibody component of antibody-drug or antibody-toxin conjugates.
REFERENCES:
patent: 4474893 (1984-10-01), Reading
patent: 4507391 (1985-03-01), Pukel et al.
patent: 4579827 (1986-04-01), Sakamoto
patent: 4612282 (1986-09-01), Schlom et al.
patent: 4613576 (1986-09-01), Cote et al.
patent: 4618577 (1986-10-01), Handley et al.
patent: 4676980 (1987-06-01), Segal
patent: 4683200 (1987-07-01), Hirohashi et al.
patent: 4693966 (1987-09-01), Houghton et al.
patent: 4693971 (1987-02-01), Fradet et al.
patent: 4708930 (1987-11-01), Kortright et al.
patent: 4713351 (1987-12-01), Knauf
patent: 4713352 (1987-12-01), Bander et al.
patent: 4737579 (1988-04-01), Hellstrom et al.
patent: 4753894 (1988-06-01), Frankel
patent: 4782015 (1988-11-01), Allison et al.
patent: 4886745 (1989-12-01), Morhenn
Blaszczth et al. Journal of Biological Chemistry vol. 262 No. 1 Issue Jan. 5, 1987 p. 372.
Brown et al. Bio. Sci. Rep. 1983; 3 163-170 (Abstract).
Nudelman et al., Journal of Biological Chemistry vol. 26 No. 24 1986, 11247.
Sears, Lancet (Apr. 1982) 762-765.
Herlyn, PNAS (1979) 76(3) 1438-1442.
Canelios, et al., "Autologous Bone Marrow Transplantation in the Treatment of Malignant Lymphoma and Hodgkins Disease," Seminars in Hematology 25, Supp. 2, 58-65 (1988).
Liu, et al., "Kimeric House-Human IgG 1 Antibody That Can Mediate Lysis of Cancer Cells," Proc. Natl. Acad. Sci. USA 84, 3439-3443 (1987).
Bregni, et al., "Elimination of Clonogenic Tumor Cells from Human Bone Marrow Using a Combination of Monoclonal Antibody: Ricin A-Chain Conjugates," Cancer Res. 46, 1208-1213 (1986).
Yang, et al., "Human Transferrin cDNA characterization in Chromosomal Location," Proc. Natl. Acad. Sci. USA 81, 2752-2756 (1984).
Trowbridge, et al., "Monoclonal Antibodies to Transferrin Receptor and Assay of Their Biological Effects," Meth. Enzymol. 265-279 (1987).
Trowbridge, et al., "Murine Cell Surface Transferrin Receptor: Studies with an Anti-receptor Monoclonal Antibody," J. Cell Physiol. 112, 403-410 (1982).
Trowbridge, I. S., Lopez, F., "Monoclonal Antibody to Transferrin Receptor Blocks Transferrin Binding and Inhibits Tumor Cell Growth in vitro," Proc. Natl. Acad. Sci. USA 79, 1175-1179 (1982).
Hopkins, C. R., Trowbridge, I. S., "Internalization and Processing of Transferrin and the Transferrin Receptor in Human Carcinoma A431 Cells," J. Cell Biol. 97, 508-521 (1983).
Borrebaeck, et al., "Human Monoclonal Antibodies Produced by Primary in vitro Immunization of Peripheral Blood Lymphocytes," Proc. Natl. Acad. Sci. USA 85, 3995-3999 (1988).
Urdal, D. L. Hakomori, S., "Tumor-associated Ganglio-N-Triosylceramide," J. Biol. Chem. 235, 10509-16 (1980).
Hellstrom, K. E., Hellstrom, I., "Anti-melanoma Antibodies for Therapy," in Human Melanoma (S. Ferrone, Ed. Springer-Verlag), pp. 1-58.
Papsidero, "Recent Progress in the Immunological Monitoring of Carcinomas Using Monoclonal Antibodies", Semin. Surg. Oncol., 1 (No. 4), pp. 171-81 (1985).
Schlom et al., "Potential Clinical Utility of Monoclonal Antibodies in the Management of Human Carcinomas", Important Adv. Oncol., pp. 170-192 1985.
Allum, et al., "Monoclonal Antibodies in the Diagnosis and Treatment of Malignant Conditions", Surg. Ann., 18, pp. 41-64 (1986).
Houghton, et al., "Monoclonal Antibodies: Potential Applications to the Treatment of Cancer", Semin. Oncol., 13 (No. 2), pp. 165-179 (1986).
Fink, et al., "Monoclonal Antibodies as Diagnostic Reagents for the Identification and Characterization of Human Tumor Antigens", Prog. Clin. Pathol. 9, pp. 121-133 (1984).
Johnston, "Applications of Monoclonal Antibodies in Clinical Cytology as Exemplified by Studies with Monoclonal Antibody B72.3", Acta. Cytol., 1 (No. 5), pp. 537-556 (1987).
Young, et al., "Production of Monoclonal Antibodies Specific for Two Distinct Steric Portions of the Glycolipid Ganglio-N-Triosylceramide (Asialo GM.sub.2)", J. Exp. Med., 150, pp. 1008-1019 (1979).
Kniep, et al., "Gangliotriaosylceramide (Asialo GM.sub.2) A Glycosphingolipid Marker for Cell Lines Derived from Patients With Hodgkin's Disease", J. Immunol., (No. 3), pp. 1591-1594 (1983).
Rosen, et al., "Analysis of Human Small Cell Lung Cancer Differentiation Antigens Using A Panel of Rat Monoclonal Antibodies", Cancer Research, 44, pp. 2052-2061 (1984).
Varki, et al., "Antigens Associates With a Human Lung Adenocarcinoma Defined By Monoclonal Antibodies", Cancer Research, 44, pp. 681-687 (1984).
Hellstrom, et al., "Antitumor Effects of L6, An IgG2a Antibody that Reacts With Most Human Carcinomas", Proc. Natl. Acad. Sci. USA, 83, pp. 7059-7063 (1986).
Embleton, et al., "Antibody Targeting of Anti-Cancer Agents", in Monoclonal Antibodies for Cancer Detection and Therapy, pp. 317-344 (Academic Press) (1985).
Domingo, et al., "Transferrin Receptor as a Target for Antibody-Drug Conjugates", Methods Enzymol. 112, pp. 238-247 (1985).
Hakomori, "Tumor-Associated Carbohydrate Antigens", Ann. Rev. Immunol. 2: 103-126 (1984).
Hellstrom, et al., "Monoclonal Mouse Antibodies Raised Against Human Lung Carcinoma", Cancer Res., 46, pp. 3917-3923 (1986).
Magnani, et al., "Mouse and Rat Monoclonal Antibodies Directed Against Carbohydrates", in Methods Enzymol., 138, pp. 484-491 (1987).
Kohler, M., Milstein, C., "Continuous Cultures of Fused Cells Secreting Antibody of Pre-Defined Specificity", Nature, 256, pp. 495-497 (1975).
Brown, et al., "Structural Characterization of Human Melanoma-Associated Antigen p97 With Monoclonal Antibodies", J. Immunol., 127 (No. 2), pp. 539-546 (1981).
Brown, et al., "Protein Antigens of Normal and Malignant Human Cells Identified by Immunoprecipitation with Monoclonal Antibodies", J. Biol. Chem., 255, pp. 4980-4983 (1980).
Yeh, et al., "Cell Surface Antigens of Human Melanoma Identified By Monoclonal Antibody", Proc. Natl. Acad. Sci. USA, 76 (No. 6), pp. 2927-2931 (1979).
Yeh, et al., "A Cell-Surface Antigen which is Present in the Ganglioside Fraction and Shared by Human Melanomae", Int. J. Cancer, 29, pp. 269-275 (1982).
Hellstrom, et al., "Immunologic Approaches to Tumor Therapy, Monoclonal Antibodies, Tumor Vaccines, and Anti-Idiotypes", in Covalently Modified Antigens and Antibodies in Diagnosis and Therapy, Quash/Rodwell (eds), pp. 24-28 (Marcel Dekker, Inc., in press).
Bagshawe, "Tumor Markers--Where Do We Go From Here", Br. J. Cancer, 48 pp. 167-175 (1983).
Rousseaux, et al., "Optimal Conditions For The Preparation of Proteolytic Fragments From Monoclonal IgG of Different Rat IgG Subclasses", in Methods Enzymol., 121, pp. 663-669 (Academic Press 1986).
Thammana, et al., "Immunoglobulin Heavy Chain Class Switch From IgM to IgG in a Hybridoma", Eur. J. Immunol., 13, p. 614 (1983).
Spira et al., "The Identification of Monoclonal Class Switch Variants By Subselection and ELISA Assay", J. Immunol. Meth., 74, pp. 307 15 (1984).
Neuberger, et al., "Recombinant Antibodies Possessing Novel Effector Functions" Nature, 312 pp. 604-608 (1984).
Ul, et al., "Chimeric Antibodies", Biotechniques,4 (No. 3), pp. 214-221 (1986).
Nudelman, et al., "Characterization of A Human Melanoma-Associated Ganglioside Antigen Defined by a Monoclonal Antibody 4 2", J. Biol. Chem., 257 (No. 1), pp. 12752-12756 (1982).
Nepom, et al., "Anti-Idiotypic Antibodies and the Induction of Specific Tumor Immunity", in Cancer and Metastasis Reviews, 6, pp. 487-501 (1987).
Ciocca, et al., "Immunohistochemical Techniques Using Monoclonal Antibodies", Meth. Enzymol., 121,
Hellstrom Ingegerd
Hellstrom Karl E.
Feisee Lila
Lacey David L.
Oncogen
LandOfFree
Monoclonal antibody to human carcinomas does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibody to human carcinomas, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody to human carcinomas will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-487233