Monitor for continuous in vivo measurement of glucose concentrat

Details Monitor for continuous in vivo measurement of glucose concentrat Monitor for continuous in vivo measurement of glucose concentrat

1982-01-27

1984-03-13

Marantz, Sidney

Surgery

Truss

Pad

204 1T, 204403, 204415, 436 95, 436827, G01N 3366, G01N 2730

Patent

active

044360940

ABSTRACT:
A method for the continuous, in vivo measurement of glucose concentration in animal body fluids such as blood, comprises implanting in the body, in registry with the system for the body fluid, a glucose monitor adapted to measure the concentration of glucose as a function of changes in such electrical charge. The glucose monitor includes an electrode with an electrical charge-transfer medium comprising a reversible complex of a binding macromolecular component and a charge-bearing carbohydrate component. The electrode includes a selectively permeable membrane permitting the ingress and egress of the body fluid. In operation, glucose present in the body fluid displaces the charge-bearing carbohydrate, which then participates in the electrical activity of the electrode so that a measurable change in electrical activity can be observed when the electrode is connected to an appropriate current-responsive meter. Preferably, the macromolecular component comprises one or more lectins, and the charge-bearing carbohydrate component may be one or more of the sugars for which testing is desired.

REFERENCES:
patent: 3615228 (1971-05-01), Thiegs
patent: 4240438 (1980-12-01), Updike
patent: 4340458 (1982-07-01), Lerner
Cerami, et al., "A Glucose-Controlled Insulin Delivery System . . . Lectin", Science, vol. 206, No. 4423, pp. 1190-1191, (1979).
Borrebaeck, C. et al., "A Binding Assay of Carbohydrates and Glycoproteins Using a Lectin Electrode", Chem. Abstr., 92:300 Abstract No. 193916j.

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