Metal radionuclide labeled proteins for diagnosis and therapy

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...

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424 9, 534 10, 534 14, 5303915, 530402, A61K 4900, A61K 4300

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active

052426793

ABSTRACT:
Protein conjugated chelated metal radionuclides are provided for use in vivo. Intermediates are provided for preparing the polypeptide compositions efficiently.

REFERENCES:
patent: 4233284 (1980-11-01), Fawzi
patent: 4287362 (1981-09-01), Yokoyama et al.
patent: 4421735 (1983-12-01), Haber et al.
patent: 4434151 (1984-02-01), Byrne et al.
patent: 4444690 (1984-04-01), Fritzberg
patent: 4510125 (1985-04-01), Grogg et al.
patent: 4564472 (1986-01-01), Ueda et al.
patent: 4670545 (1987-06-01), Fritzberg et al.
patent: 4671958 (1987-06-01), Rodwell et al.
patent: 4673562 (1987-06-01), Davison et al.
patent: 4861869 (1989-08-01), Nicolotti et al.
patent: 4963682 (1990-10-01), Bodor
patent: 4963688 (1990-10-01), Bodor
patent: 4980147 (1987-06-01), Davison et al.
Fritzberg et al., J. Nucl. Med., vol. 23, pp. 592-598 (1982), "Synthesis and biological evaluation of Tc-99m N,N'-Bis (mercaptoacetyl)-2,3-diaminopropanoate: A potential replacement for [.sup.131 I]o-iodohippurate".
Greene, T.W., "Protective Groups in Organic Synthesis", John Wiley and Sons, New York, New York, pp. 206-07 (1981).
Schneider et al., J. Nucl. Med., vol. 25, pp. 223-229 (1984), "N,N'-bis-S-Benzoylmercaptoacetamido ethylenediamine and propylenediamine ligands as renal function imaging agents. I. Alternate synthetic methods".
Fritzberg, J. Nucl. Med. Tech. pp. 177-188 (1984), "Current status of renal radiopharmaceuticals".
Davison et al., Inorganic Chem., 20, pp. 1729-33 (1981), "A new class of oxotechnetium (5+) chelate complexes containing a TcON.sub.2 S.sub.2 core".
Costello et al., J. Nucl. Med., 24, pp. 353-55 (1983), "The investigation of radiopharmaceutical components by fast atom bombardment mass spectrometry=The identification of Tc-HIDA and the epimers of Tc-CO.sub.2 DADS".
Byrne and Tolman, J. Nucl. Med. Proc. 30th Ann. Meeting, p. 126., "Technetium-99m bifunctional chelating agent-thiolactone for coupling to biomolecules, N.sub.2 S.sub.2 ligand for chelation to technetium".
Fritzberg et al., Amer. Chem. Soc. Abstracts, Abstract No. 70, (1984), "Labeling of proteins by chelate conjugation with Tc-99m and Re-188".
Baidoo et al., J. Nucl. Med., vol. 27, No. 6, p. 1050, Abstract No. 713, (Jun. 1986), "Synthesis of Tc-99m-N.sub.2 S.sub.2 complexes via the p-methoxy benzyl protected thiol ligand".
Kung et al., J. Nucl. Med., vol. 27, No. 6, p. 1051, Abstract No. 719, (Jun. 1986), "New Tc-99 complexes based on N.sub.2 S.sub.2 ligands".
Liang et al., J. Nucl. Med., vol. 27, No. 6, p. 1051, Abstract No. 720, (Jun. 1986), "Serum-stability and non-specific binding of technetium-99m labeled diaminodithiol for protein labeling".
Kasina et al., J. Med. Chem., 29, pp. 1933-40 (1986), "Tissue distribution properties of technitium-99m-diamide dimercaptide complexes and potential use as renal radiopharmaceuticals".
Arano, Y., Int. J. Nucl. Med. Biol., vol. 12, No. 6, pp. 425-430 (1986), "Synthesis and evaluation of a new bifunctional chelating agent for 99mTc labeling proteins: p-Carboxyethylphenylglyoxal-di(N-methylthiosemicarbazone)".
Kasina et al., Sixth international Symp. on Radiopharmaceutical Chem., Boston, 1986, "Application of diamide dimercaptide N.sub.2 S.sub.2 bifunctional chelating agents for 99mTc-labeling of proteins".
Copy of the Search Report received in European patent application EP 86 10 0360, related to the above-captioned U.S. application.
Fritzberg, A. R., (Nuklearmedizin) Nucl.-Med. (1987) 26, pp. 7-12, "Advances in .sup.99m Tc-labeling of antibodies".

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