Preparation of veratryl cyanide

Details Preparation of veratryl cyanide Preparation of veratryl cyanide

1986-07-22

1987-04-28

Torrence, Dolph H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

C07C12004

Patent

active

046616101

ABSTRACT:
Veratryl cyanide is prepared by chloromethylating veratrol in solution in toluene and then reacting the resulting veratryl chloride with from 1 to 5 moles of an alkali metal cyanide, by a process in which the toluene from the chloromethylation is not removed for the reaction with cyanide, and from 3 to 25% by weight, based on veratryl chloride, of water, from 5 to 50% by weight, based on toluene, of a ketone of 3 to 6 carbon atoms and from 0.1 to 10% by weight, based on veratryl chloride, of a phase transfer catalyst are added before the reaction with cyanide.

REFERENCES:
patent: 2734908 (1956-02-01), Dengel
Knabe et al., J. Knabe, Arch. Pharmaz. 296, 591 (1963).
Fujii et al., J. Knabe, Arch. Pharmaz. Bull, 19, 1374 (1971).
Stroh et al., "Herstellung von Chlorverbindungen", Houben Weyl, Methoden der org. Ch., 4th ed., Georg-Thieme Publisher, Stuttgart 1962, vol. 513, p. 1001.

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