Bicyclo heptane and bicyclo octane substituted inhibitors of cho

Details Bicyclo heptane and bicyclo octane substituted inhibitors of cho Bicyclo heptane and bicyclo octane substituted inhibitors of cho

1988-12-21

1990-03-06

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514824, 549292, A61K 31365, C07D30930

Patent

active

049066579

ABSTRACT:
Certain bicyclo [2.2.1] heptane and bicyclo [2.2.2] octane substituted tetrahydro-2H-pyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.

REFERENCES:
patent: 3983140 (1976-09-01), Endo et al.
patent: 4049495 (1977-09-01), Endo et al.
patent: 4137322 (1979-01-01), Endo et al.
patent: 4198425 (1980-04-01), Mistui et al.
patent: 4255444 (1981-03-01), Oka et al.
patent: 4262013 (1981-04-01), Mistui et al.
patent: 4375475 (1983-03-01), Willard et al.
patent: 4647576 (1987-03-01), Hoefle et al.
patent: 4681893 (1987-07-01), Roth
M. S. Brown & J. L. Goldstein, New England Journal of Medicine (1981), 305, No. 9,515-517.
Journal of the American Medical Association (1984), 215, No. 3, 351-374.
F. M. Singer et al, Proc. Soc. Exper. Biol. Med. (1959), 102, 370-373.
F. H. Hulcher, Arch. Biochem. Biophys., 30 (1971), 146, 422.
Brown et al, J. Chem. Soc. Perkin I, (1976), 1165-1170.

Affiliated with

Also associated with

Rating

Bicyclo heptane and bicyclo octane substituted inhibitors of cho does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bicyclo heptane and bicyclo octane substituted inhibitors of cho, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bicyclo heptane and bicyclo octane substituted inhibitors of cho will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-47757