Antihypercholesterolemic lactone compounds, compositions and use

Details Antihypercholesterolemic lactone compounds, compositions and use Antihypercholesterolemic lactone compounds, compositions and use

1986-05-05

1987-04-28

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514222, 514228, 514234, 514252, 514316, 514319, 514422, 514459, 544 584, 544 79, 544121, 544130, 544141, 544149, 544357, 544364, 544372, 544374, 546187, 546206, 548517, 548524, 549292, A61K 31365, A61K 31535, C07D30930, C07D41312

Patent

active

046614834

ABSTRACT:
Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1## and pharmaceutically acceptable salts of the compounds (II) in which Z is hydrogen are disclosed.

REFERENCES:
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4444784 (1984-04-01), Hoffman et al.
patent: 4448979 (1984-05-01), Terahara et al.
patent: 4517373 (1985-05-01), Terahara et al.

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