Traumatic and ischemic brain injury treatment with opiate-recept

Details Traumatic and ischemic brain injury treatment with opiate-recept Traumatic and ischemic brain injury treatment with opiate-recept

1988-12-21

1990-03-06

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

049066374

ABSTRACT:
The present invention involves methods of inducing opiate-receptor antagonistic activity in a patient suffering from ischemic or traumatic brain injury by administering to said patient an effective amount of an opiate-receptor antagonist having enhanced activity at the kappa-opiate receptor suitable to permit the induction of opiate-receptor antagonistic activity.

REFERENCES:
Chem. Abst-106-113401G (1987).
Chem. Abst-97-208277F (1982).
Faden et al., "Opiate Antagonist WIN 44,441-3 Stereospecifically Improves Neurologic Recovery After Ischemic Spinal Injury" Neurology, vol. 35, No. 9, pp,. 1311-1315, Sep. 1985.
Ward et al., "Multiple Opioid Receptor Profile in Vitro and Activity in Vivo of the Potent Opioid Antagonist WIN" 44,441-3, Life Sciences, vol. 33, Sup. I, pp. 303-306, 1983.

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