Reduction of 4-oxo-tetraalkylpiperidines

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D21112, C07D21114

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active

042085250

ABSTRACT:
Process for the reduction of 4-oxo-2,2,6,6-tetraalkylpiperidines, and the N-alkyl derivatives thereof, to 2,2,6,6-tetraalkylpiperidines unsubstituted in the 4-position, wherein the reduction is carried out with catalytically activated hydrogen in an acid medium.

REFERENCES:
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Theilheimer, W., Synthetic Methods of Organic Chemistry, Interscience, New York, vol. 16 (1962), p. 51, vol. 17 (1963), p. 28.
Barnes, R., et al., J. Am. Chem. Soc., 80, 4714-4716 (1958).
Mailey, E., et al., J. Org. Chem., 22, 1061-1065 (1957).
Fankhauser, R., et al., Helv. Chim. Acta, 49, 690-695 (1966).
Fieser, L., et al., Organic Chemistry, Reinhold Pub. Co., New York, 1960, pp. 206, 231 and 544.
Augustine, R., Catalytic Hydrogenation, Marcel Dekker, New York, 1965, pp. 82-83, 90-91 and 106 (1965).
House, H. O., Modern Synthetic Reactions, W. A. Benjamin, New York, 1965, pp. 2 and 6-7.

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