Process for purifying thienamycin

Details Process for purifying thienamycin Process for purifying thienamycin

1978-03-13

1980-04-15

Lee, Mary C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424123, 424124, 424274, 204158R, 435 47, C07D48904, A61K 3140

Patent

active

041983386

ABSTRACT:
Fermentation broths or impure solutions containing thienamycin, a substance having antibiotic activity against gram-negative and gram-positive microorganisms, are purified using a sequence of ion exchange resins, starting with an anion exchange resin of the polystyrene-trimethylammonium type in the HCO.sub.3 -cycle, and ending with absorption on and elution from a polymeric cross-linked polystyrene-type resin adsorbent. Variations in the intermediate steps, e.g. different resins and eluates are possible and are illustrated within.

REFERENCES:
patent: 3950357 (1976-04-01), Kahan et al.
patent: 4000161 (1976-12-01), Geogelman et al.

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