Chemical process for preparing androsta-4-ene 17.alpha.-carboxyl

Details Chemical process for preparing androsta-4-ene 17.alpha.-carboxyl Chemical process for preparing androsta-4-ene 17.alpha.-carboxyl

1978-04-05

1980-04-15

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603971, 2602395, 26039745, C07J 100

Patent

active

041983360

ABSTRACT:
This invention is a process for preparing 3-keto-androst-4-ene 17.alpha.-carboxylic acids, androsta-1,4-diene 17.alpha.-carboxylic acids and their 17.alpha.-esters by reacting a corresponding 21-hydroxypregn-4-ene-3,20-dione, 21-hydroxypregna-1,4-diene-3, 20-dione, or their 21-esters with an alkali metal carbonate base in a lower alkanol in the presence of oxygen. The 17.alpha.-esters are formed by reacting the 17.alpha.-carboxylic acid with a suitable alkylating agent.

REFERENCES:
patent: 3828080 (1974-08-01), Phillipps et al.
patent: 4119625 (1978-10-01), Schmidlin
"Steroid Reactions" by Djerassi, (1963).
"Organic Reactions in Steroid Chemistry", (1972), by Fried et al., p. 148.

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