Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-07-22
1995-09-05
Fan, Jane
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546269, A61K 3144, C07D40504
Patent
active
054479436
ABSTRACT:
Compounds of the Formula: ##STR1## wherein: R.sup.1-7 are as defined in the specification. The compounds and salts exhibit useful pharmacological properties, including potassium channel activating properties and 5-lipoxygenase inhibiting properties, and in particular are useful as smooth muscle relaxants and bronchodilators.
REFERENCES:
patent: 5021432 (1991-06-01), Yanamaka et al.
Potassium Channel Modulators, by Robertson et al., J. Med. Chem., 33, 1529-1541 (1990).
Relaxant Activity of 4-Amidobenzopyrans, by Buckle et al., J. Med. Chem., 33, 3028-3034 (1990).
Structure-Activity Relationships of K.sup.+ Channel Openers, by Edwards et al., Trends in Pharmacological Sciences, 11, 417-422 (1990).
Hicks Peter E.
Lochead Alistair W.
Navet Michel J.
Fan Jane
Lewis Brian
Syntex (U.S.A.) Inc.
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