Synthesis of bisindolylmalimides

Details Synthesis of bisindolylmalimides Synthesis of bisindolylmalimides

1999-01-21

2000-10-17

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548466, 548428, C07D40314, C07D40304

Patent

active

061334529

ABSTRACT:
The present invention provides for the reaction of optionally substituted indole-3-acetamides with optionally substituted methyl indole-3-glyoxyl reagent to prepare potent PKC inhibitors. The reaction is very efficient and robust macrocyclization methodology.

REFERENCES:
patent: 5057614 (1991-10-01), Davis et al.
patent: 5541347 (1996-07-01), Faul et al.
Davis et al., Inhibitors of Protein Kinase C. 1. 2,3-Bisarylmaleimides, J. Med. Chem, Jan. 1992, vol. 35, No. 1, pp. 177-184.

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