Novel soft N-chloroamino alcohol derivatives exhibiting antibact

Details Novel soft N-chloroamino alcohol derivatives exhibiting antibact Novel soft N-chloroamino alcohol derivatives exhibiting antibact

1977-06-06

1978-05-30

Turner, V. D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424309, 424311, 424325, 424330, A61K 3144

Patent

active

040924203

ABSTRACT:
There is provided, a novel class of compounds exhibiting antibacterial activity and having the formula: ##STR1## wherein X and Y each represent a member which may be the same or different selected from the group consisting of H and Cl with the proviso that X and Y cannot represent H simultaneously; R.sub.1 and R.sub.2 each represent a member which may be the same or different selected from the group consisting of an n- or branched alkyl group of from 1 to 20 carbon atoms, an aryl group (phenyl, naphthyl, etc.) and a ##STR2## WHEREIN M REPRESENTS AN INTEGER OF FROM 2 TO 5; N REPRESENTS AN INTEGER OF 1 TO 8; AND Z represents a member selected from the group consisting of an --OOCR.sub.3 group, an --OR.sub.3 group and an --OCH.sub.2 OR.sub.3 group, wherein R.sub.3 represents a member selected from the group consisting of an n- or branched alkyl group of 1 to 20 carbon atoms, a phenyl group, a naphthyl group, a benzyl group, ##STR3## WHEREIN X is a halogen atom (Cl, Br, I), ##STR4## WHEREIN R.sub.4 represents a member selected from the group consisting of H, an n- or branched alkyl group, a benzyl group, and a --(CH.sub.2).sub.p COOH group, wherein p represents an integer of 1 to 4, and wherein W.sup..theta. represents a non-toxic pharmaceutically acceptable inorganic or organic anion.

REFERENCES:
patent: 3830806 (1974-08-01), Raabe et al.
Chemical Abstracts, vol. 80 (1974), p. 129249u.

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