Diaryl-5-alkyl-5-methyl-2-(5H)-furanones as selective cyclooxyge

Details Diaryl-5-alkyl-5-methyl-2-(5H)-furanones as selective cyclooxyge Diaryl-5-alkyl-5-methyl-2-(5H)-furanones as selective cyclooxyge

1998-10-16

2000-10-17

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514473, 5462844, 549323, A61K 31443, A61K 3134, C07D40504, C07D30758

Patent

active

061332925

ABSTRACT:
The invention encompasses compounds of Formula I as well as a method of treating COX-2 mediated diseases comprising administration to a patient need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I ##STR1## e.g. (5R)-3-(3,4-difluorophenyl)-5-ethyl-5-methyl-4-[4-(methylsulfonyl)phenyl]- 2,5-dihydro-2-furanone.

REFERENCES:
patent: 5474995 (1995-12-01), Ducharme et al.
patent: 5840746 (1998-11-01), Ducharme et al.

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