Nitrosated and nitrosylated phosphodiesterase inhibitor compound

Details Nitrosated and nitrosylated phosphodiesterase inhibitor compound Nitrosated and nitrosylated phosphodiesterase inhibitor compound

1999-02-01

2000-10-17

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544256, A61K 31445, C07D48704

Patent

active

061332720

ABSTRACT:
Disclosed are nitrosated and/or nitrosylated phosphodiesterase inhibitors having the formula NO.sub.n N-PDE inhibitor where n is 1 or 2. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides a composition comprising a therapeutically effective amount of an phosphodiesterase inhibitor (PDE inhibitor), which can optionally be substituted with at least one NO or NO.sub.2 moiety, and one to ten fold molar excess of a compound that donates, transfers or releases nitrogen monoxide as a charged species, i. e., nitrosonium (NO.sup.+) or nitroxyl (NO.sup.-), or as the neutral species, nitric oxide (NO.) or which stimulates endogenous EDRF production. The invention also provides compositions comprising such compounds in a pharmaceutically acceptable carrier. The invention also provides methods for treating sexual dysfunctions in males and females.

REFERENCES:
patent: 4308278 (1981-12-01), Schneider et al.
patent: 4963541 (1990-10-01), Brooks et al.
patent: 5171217 (1992-12-01), March et al.
patent: 5190967 (1993-03-01), Riley
patent: 5196426 (1993-03-01), Saccomano et al.
patent: 5223504 (1993-06-01), Noverola et al.
patent: 5254575 (1993-10-01), Pick et al.
patent: 5340827 (1994-08-01), Beeley et al.
patent: 5380758 (1995-01-01), Stamler et al.
patent: 5426107 (1995-06-01), Bell et al.
patent: 5438060 (1995-08-01), Miyazaki et al.
patent: 5439938 (1995-08-01), Snyder et al.
patent: 5491147 (1996-02-01), Boyd et al.
patent: 5492911 (1996-02-01), Stief
patent: 5543430 (1996-08-01), Kaesemeyer
patent: 5545647 (1996-08-01), Tanaka et al.
patent: 5565466 (1996-10-01), Gioco et al.
patent: 5583101 (1996-12-01), Stamler et al.
patent: 5618814 (1997-04-01), Heckel et al.
patent: 5645839 (1997-07-01), Chobanian et al.
patent: 5646181 (1997-07-01), Fung et al.
patent: 5698589 (1997-12-01), Allen
patent: 5767160 (1998-06-01), Kaesemeyer
patent: 5874437 (1999-02-01), Garvey et al.
patent: 5877216 (1999-03-01), Place et al.
Zorgniotti et al, Int. J. Impotence Res., 6:33-36 (1994).
Chemical Abstracts, 120(1):612, Abstract 5451d (1994).
Chen et al, BJU International, 83:269-273 (1999).
Boolell et al, International Journal of Impotence Research, 8:47-52 (1996).
Krane et al, New England Journal of Medicine, 321(24):1648-1659 (1989).
Trigo-Rocha et al, Neurourol. Urodyn., 13(1):71-80 (1994).
Sparwasser et al, J. Urol., 152:6, Pt. 1, pp. 2159-2163 (1994).
Mathers et al, European Urology, 35(suppl 2):67 (abstract 266) (1999).
Park et al, Biochem. Biophys. Res. Commun., 249(3):612-617 (1998).
Terrett et al, Bioorg. Med. Chem. Lett., 6(15):1819-1824 (1996).

Affiliated with

Also associated with

Rating

Nitrosated and nitrosylated phosphodiesterase inhibitor compound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nitrosated and nitrosylated phosphodiesterase inhibitor compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nitrosated and nitrosylated phosphodiesterase inhibitor compound will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-469205