Novel crystalline forms of prazosin hydrochloride

Details Novel crystalline forms of prazosin hydrochloride Novel crystalline forms of prazosin hydrochloride

1976-03-01

1978-05-30

Rollins, Alton D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424251, C07D23994

Patent

active

040923150

ABSTRACT:
The invention relates to novel and valuable crystalline forms of the hypotensive agent prazosin hydrochloride. The anhydrous .alpha.-form is preferred because it is relatively non-hygroscopic and hence possesses important advantages in handling and formulation. The polyhydrate form of prazosin hydrochloride is preferred because of its low, uniform rate of dissolution.

REFERENCES:
patent: 3635979 (1972-01-01), Hess
patent: 3663706 (1972-05-01), Hess
Weissberger, A. Ed., "Technique of Organic Chem.", vol. III, Interscience N.Y., N.Y., (1950).

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