Endoderm, cardiac and neural inducing factors

Details Endoderm, cardiac and neural inducing factors Endoderm, cardiac and neural inducing factors

1997-06-18

2000-10-17

Romeo, David

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

4241981, 530350, A61K 3818, C07K 1446

Patent

active

061332321

ABSTRACT:
Two novel proteins have been designated "cerberus" and "frzb-1," respectively. Cerberus is expressed as a secreted peptide during embryogenesis of the Xenopus embryo, and is expressed specifically in the head organizer region. This new molecule has endodermal, cardiac, and neural tissue inducing activity, that should prove useful in therapeutic, diagnostic, and clinical applications requiring regeneration, differentiation, or repair of these and other tissues. Frzb-1 is a soluble antagonist of growth factors of the Wnt family that acts by binding to Wnt growth factors in the extracellular space. A third novel protein is designated "PAPC" which promotes the formation of dorsal mesoderm and somites in the embryo.

REFERENCES:
patent: 5457048 (1995-10-01), Pasquale et al.
Ham et al. Media and growth requirements. Methods Enzymology, (Mar. 1979), vol. 58, pp. 44-93.
Bouwmeester et al., "Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer," Nature, 382:6592, pp. 595-601 (Aug. 15, 1996).
Christian et al., "Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus," Genes & Development, pp. 13-28 (1993).
Gribskov et al, "[9] Profile Analysis," Methods of Enzymology, 183, pp. 146-159 (1990).
Krasnow et al., "dishevelled is a component of the frizzled signaling pathway in Drosophila," Development, 121, pp. 4095-4102 (1995).
Leyns et al., "Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer," Cell, 88, pp. 747-756 (Mar. 21, 1997).
Mayr et al., "Fritz: a secreted frizzled-related protein that inhibits Wnt activity," Mechanisms of Development, 63, pp. 109-125 (1997).
Moon et al., "Structural Related Receptors and Antagonists Compete for Secreted Wnt Ligands," Cell, 88, pp. 725-728 (Mar. 21, 1997).
Sano et al., "Protocadherins: a large family of cadherin-related molecules in central nervous system," The EMBO Journal, 12:6, pp. 2249-2256 (1993).
Sasai et al., "Xenopus chordin: A Novel Dorsalizing Factor Activated by Organizer-Specific Homeobox Genes," Cell, 79, pp. 779-790 (Dec. 2, 1994).
Sasai et al., "Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus," Nature, 376, pp. 333-336 (Jul. 27, 1995).
Sokol et al., A Mouse Macrophage Factor induces Head Structures and Organizes a Body Axis in Xenopus, Science, 249, pp. 561-564 (Aug. 3, 1990).
Smith et al., "Injection Xwnt-8 RNA Acts Early in Xenopus Embryos to Promote Formation of a Vegetal Dorsalizing Center," Cell67, pp. 753-765 (Nov. 15, 1991).
Smith et al., "Expression Cloning of noggin, A new Dorsalizing Factor Localized to the Spemann Organizer in Xenopus Embryos," Cell, 70 , pp. 829-840 (Sep. 4, 1992).
Vinson et al., "A Drosophilia tissue polarity locus encodes a protein containing seven potential transmembrane domains," Nature, 338, pp. 263-264 (Mar. 16, 1989).
Vinson et al., "Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drospohila," Nature, 329 pp. 549-551 (Oct. 8, 1987).
Wang et al., "A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophilia Tissue Polarity Gene frizzled," J. of Biol. Chem., 271:8, pp. 4468-4476 (Feb.23, 1996).
Wang et al. "Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8," Cell, 88, pp. 757-766 (Mar. 21, 1997).
Nathan C; Sporn M. Cytokines in context. J. Cell Biol., (Jun. 1991) 113 (5) 981-986.
Marieb E N. In, Human Anatomy and Physiology, Second Edition. 1992. The Benjamin/Cummings Publishing Co., Inc. pp. 373-375.
Daniel et al. Virology, (Aug. 1, 1994) 202 (2) 540-549.

Affiliated with

Also associated with

Rating

Endoderm, cardiac and neural inducing factors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Endoderm, cardiac and neural inducing factors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Endoderm, cardiac and neural inducing factors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-468918