Process to produce midazolam

Details Process to produce midazolam Process to produce midazolam

1998-01-20

1999-08-24

O'Sullivan, Peter

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540561, 540562, 544283, 556137, 558 9, C07D24320

Patent

active

059426144

ABSTRACT:
The present invention discloses new processes in the preparation of midazolam (VII), ##STR1## a commercially important pharmaceutical, as well a new intermediates in those processes from a known benzophenone (I) starting material.

REFERENCES:
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patent: 3998809 (1976-12-01), Milkowski et al.
patent: 4280957 (1981-07-01), Walser et al.
patent: 4377523 (1983-03-01), Walser et al.
J. Heterocyclic Chem., 13, pp. 433-437 (1976), Fryer et al.
J. Org. Chem., 43, pp. 936-944 (1978), Walser et al.
Aldrichimica Acta, 23(1), pp. 13-19 (1990), Griffith et al.
Tetrahedron Letters, 35(35), pp. 6567-6570 (1994), Goth et al.
J. Org. Chem., 40(2), 153 (1975), Walser et al.

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