Prevention of precipitated acute urinary retention

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3147

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active

059425199

ABSTRACT:
This invention is concerned with the prevention of precipitated acute urinary retention in a subject male susceptible thereto by the administration of an inhibitor of 5.alpha.-reductase to the subject. The present invention also provides for a method of reducing the risk of precipitated acute urinary retention by the administration of a 5.alpha.-reductase inhibitor to the subject at risk therefor.

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Barry et al., The Natural History of Patients with Benign Prostatic Hyperplasia as Diagonosed by North American Urologists. The J. of Uroloty, vol. 157, pp. 10-15 (1997).
MacConnell et al., The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment among Men with Benign Prostatic Hyperplasia, N. Eng. J. of Medicine, vol. 338(9), Feb. 1998, pp. 557-563 (some of this material was presented at the SIU 24th Congress, Montreal, Canada, Sep. 7-11, 1997.
Anderson et al., Finasteride Significantly Reduces Acute Urinary Retention and Need for Surgery in Patients with Symptomatic Benign Prostatic Hyperplasia, Urology, vol. 49, No. 6 (1997), pp. 839-845.
Jacobsen et al., Natural History of Prostatism: Risk Factors for Acute Urinary Retention. The J. of Urology, vol. 158, pp. 481-487 (1997).
Lieber, Proscar.TM. Long-Term Efficacy and Safety Studies (Pless) presented at Congress of the European Association of Urology, Mar. 21, 1998, Barcelona, Spain.

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