Method for binding antibodies to a surface such that they remain

Details Method for binding antibodies to a surface such that they remain Method for binding antibodies to a surface such that they remain

1975-08-27

1978-05-30

Marantz, Sidney

Chemistry: physical processes

Physical processes

Crystallization

23253TP, 1951035R, 1951035A, 1951035V, 424 12, G01N 3316, G01N 3102

Patent

active

040921166

ABSTRACT:
In carrying out an immunological reaction or diagnostic test, an immunologically inert organic compound of sufficient quantity is added to an aqueous medium containing an immunologically reactive antigen. A substrate is then treated with the aqueous medium and on the surface thereof is formed, by adsorption, a monomolecular layer of the reactive antigen molecules separated from each other to distances of several hundred Angstrom by the inert organic molecules. Subsequent immersion of the coated substrate in aqueous media alternately containing an immunologically reactive antibody specific to the antigen, and then again containing the reactive antigen, forms a multimolecular immunologically complexed film on the substrate.

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