Method for obtaining chromosome painting probes

Details Method for obtaining chromosome painting probes Method for obtaining chromosome painting probes

1999-05-04

2000-10-17

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

436 94, 536 243, 536 2431, 536 254, C12Q 168, C07H 2104, G01N 3300

Patent

active

061329746

ABSTRACT:
A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a frequency of a second, different type of chromosome aberration present in the sample; and comparing the frequency of the first type of chromosome aberration to the frequency of the second type of chromosome aberration. A method is also provided for using that clastogenic signature to identify a clastogenic agent or dosage to which the cells were exposed.

REFERENCES:
patent: 5538869 (1996-07-01), Siciliano et al.
patent: 5663319 (1997-09-01), Bittner et al.
patent: 5693464 (1997-12-01), Trent et al.
patent: 5756696 (1998-05-01), Gray et al.
patent: 5798262 (1998-08-01), Garini et al.

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