Multivesicular liposomes with controlled release of encapsulated

Details Multivesicular liposomes with controlled release of encapsulated Multivesicular liposomes with controlled release of encapsulated

1998-03-20

2000-10-17

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424417, 424DIG8, 264 41, 264 43, 264 46, A61K 9127

Patent

active

061327662

ABSTRACT:
A multivesicular liposome composition containing at least one acid other than a hydrohalic acid and at least one biologically active substance, the vesicles having defined size distribution, adjustable average size, internal chamber size and number, provides a controlled release rate of the biologically active substance from the composition. A process for making the composition features addition of a non-hydrohalic acid effective to sustain and control the rate of release of an encapsulated biologically active substance from the vesicles at therapeutic levels in vivo.

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