Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1999-02-19
2000-10-17
Prouty, Rebecca E.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 941, 424 9463, 514 12, 435212, 435219, 435195, C12N 948
Patent
active
061327174
ABSTRACT:
The invention is based on the finding the furin belongs to a family of endoproteolytically active enzymes and relates to a process in the in vitro cleavage of a protein by treating the protein in the presence of a Ca.sup.2+ ions with furin, or an endoproteolytically active fragment, derivative or fusion protein of furin. The invention can be used for the (micro) biological production of a protein by culturing genetically engineered cells expressing a pro-form of the protein as well as furin and isolating the protein formed. The invention also relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable carriers, diluents or adjuvants, as well as an endoproteolytically active amount of furin, or a fragment or derivative of furin having an endoproteolytic activity.
REFERENCES:
Van den Ouweland et. al., Nucleotide sequence analysis of the human fur gene, Nucleic Acids Res. 17, 7101-7102, 1989.
Koning Piet Nico
Roebroek Antonius Johannes
van de Ven Willem Jan
van den Ouweland Anna Maria
van Duijnhoven Johannes Lambertus
Hutson Richard
Katholieke Universiteit Leuven
Prouty Rebecca E.
van de Ven William Jan Marie
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