Molecules of the follistatin-related protein family and uses the

Details Molecules of the follistatin-related protein family and uses the Molecules of the follistatin-related protein family and uses the

1997-11-17

1999-08-24

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525411, 435325, 4353201, 536 231, 536 235, 935 22, C12P 2106, C07H 2102, C07H 2104, C12N 1500

Patent

active

059424206

ABSTRACT:
Novel FMCP polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FMCP proteins, the invention further provides isolated FMCP fusion proteins, antigenic peptides and anti-FMCP antibodies. The invention also provides FMCP nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a FMCP gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

REFERENCES:
Amthor, H. et al. "The Expression and Regulation of Follistatin and a Follistatin-like Gene during Aviation Somite Compartmentalization and Myogenesis" Developmental Biology 178:343-362 (1996).
Besecke, L.M. et al. "Pituitary Follistatin Regulates Activin-Mediated Production of Follicle-Stimulating Hormone during the Rat Estrous Cycle" Endocrinology 138(7):2841-2848 (1997).
DePaolo, L.V. et al. "Follistatin and Activin: A Potential Intrinsic Regulatory System within Diverse Tissues" Proceedings of the Society for Experimental Biological and Medicine 198:500-512 (1991).
DePaolo, L.V. "Inhibins, Activins, and Follistatins: The Saga Continues" Proceedings of the Society for Experimental Biological and Medicine 214:328-339 (1997).
Eib, D.W. et al. "A Novel Transmembrane Protein with Epidermal Growth Factor and Follistatin Domains Expressed in the Hypothalamo-Hypophysial Axis of Xenopus laevis" Journal of Neurochemistry 67:1047-1055 (1996).
Esch, F.S. et al. "Structural Characterization of Follistatin: A Novel Follicle-Stimulating Hormone Release-Inhibiting Polypeptide for the Gonad" Molecular Endocrinology 1(11):849-855.
Hashimoto, O. et al. "A Novel Role of Follistatin, an Activin-binding Protein, in the Inhibition of Activin Action in Rat Pituitary Cells" The Journal of Biological Chemistry 272(21):13835-13842 (1997).
Hohenester, E. et al. "Crystal Structure of a Pair of Follistatin-like and EF-Hand Calcium-Binding Domains in BM-40" Embo 16(13):3778-3786 (1977).
Lane, T. et al. "The Biology of SPARC, a Protein that Modulates Cell-Matrix Interactions" The FASEB Journal 8:163-173(1994).
Link, B.A. et al. "Opposing Effects of Activin A and Follistatin on Developing Skeletal Muscle Cells" Experimental Cell Research 233:350-362 (1997).
Michel, U. et al. "Follistatins: More than Follicle-Stimulating Hormone Suppressing Proteins" Molecular and Cellular Biology 91:1-11 (1993).
Patel, K. et al. "Cloning and Early Dorsal Axial Expression of Flik, a Chick Follistatin-Related Gene: Evidence for Involvement in Dorsalization/Neural Induction" Developmental Biology 178:327-342 (1996).
Petralia, F. "Inhibin, Activin and Follistatin in the Human Placenta--a New Family of Regulatory Proteins" Placenta 18:3-8 (1997).
Patthy, L. et al. "Functions of Agrin and Agrin-related Proteins" TINS 16(2):76-81 (1993).
Sakamoto, Y. et al. "Determination of Free Follistatin Levels in Sera of Normal Subjects and Patients with Various Diseases" European Journal of Endocrinology 135:345-351 (1996).
Shibanuma, M. et al. "Cloning from a Mouse Osteoblastic Cell Line of a Set of Transforming-growth-factor-.beta.1-regulated Genes, One of which Seems to Encode a Follistatin-related Polypeptide" European Journal of Biochemistry 217:13-19 (1993).
Shimonaka, M. et al. "Follistatin Binds to both Activin and Inhibin through the Common Beta-Subunit" Endocrinology 128(6):3313-3315 (1991).
Zwijsen, A. et al. "Characterization of a Rat C.sub.6 Glioma-secreted Follistatin-related Protein (FRP): Cloning and Sequence of the Human Homologue" European Journal of Biochemistry 225:937-946 (1994).

Affiliated with

Also associated with

Rating

Molecules of the follistatin-related protein family and uses the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Molecules of the follistatin-related protein family and uses the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Molecules of the follistatin-related protein family and uses the will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-465694