Polynucleotides encoding human G-protein coupled receptor HIBEF5

Details Polynucleotides encoding human G-protein coupled receptor HIBEF5 Polynucleotides encoding human G-protein coupled receptor HIBEF5

1995-06-06

1999-08-24

Teng, Sally P.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525411, 4353201, 435325, 536 235, C12N 1512, C07K 14705

Patent

active

059424141

ABSTRACT:
Human G-protein Coupled receptor HIBEF51 polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the human G-protein Coupled receptor HIBEF51 nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.

REFERENCES:
Ross, P.C. et al., Proc. Of the National Academy of Science, 87:3052-3056 (1990).
Libert, F. et al., Science, 244:569-572 (1989).
Eva, C. et al., FEBS Letters, 271:81-84 (1990).
Hla, T. et al., The Journal of Biol. Chemistry, 265 (16):9308-9313 (1990).
Meyerhof, W. et al., FEBS Letters, 284(2):155-160 (1991).
Pepperl, D.J. et al., CRC Press, 45-46 (1994).
Fraser et al., J. of Biol. Chem., vol. 264, 11754-11761, Jul. 15, 1989.

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